| Name | Imipramine |
| Description | Imipramine (Dimipressin) is an orally active Fascin1 inhibitor with antidepressant and antitumor activity.Imipramine inhibits the 5-hydroxytryptamine transporter (IC50: 32 nM), induces apoptosis, and induces autophagy in U-87MG glioma cells.Imipramine has neuroprotective and immunomodulatory activities, inhibits TNT, and is used to label brain blood vessels.Imipramine is a neuroprotective and immunomodulatory compound. Imipramine has neuroprotective and immunomodulatory activities, inhibits invasion and migration of TNBC cells, and can be used to study breast cancer and epilepsy. |
| In vitro | In DLD-1, HCT-116, and SW-480 cell lines, Imipramine (0.5-300 μM; 3 days) inhibited cell viability, with HCT-116 being more sensitive to it compared to DLD-1 and SW-480[1]. |
| In vivo | In male C57BL/6 mice (6-8 weeks old) exposed to repeated social defeat (RSD) and home cage control (HCC), Imipramine (20 mg/kg or 15 mg/kg; administered intraperitoneally or orally, daily for 24 days) reversed RSD-induced social avoidance behavior, significantly increasing interaction time, and significantly decreased stress-induced mRNA levels for IL-6 in brain microglia[4]. |
| Storage | Store under nitrogen | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween-80+45% Saline : 5 mg/mL (17.83 mM), Sonication is recommended.
DMSO : 100 mg/mL (356.62 mM), Sonication is recommended.
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| Keywords | Imipramine | fascin 1 | Apoptosis |
| Inhibitors Related | Stavudine | Aceglutamide | Hemin | Urea | Tamoxifen | Guanidine hydrochloride | Hydroxychloroquine | Metronidazole | Formamide | Paeonol | Naringin | Alginic acid |
| Related Compound Libraries | Apoptosis Compound Library | Failed Clinical Trials Compound Library | Bioactive Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Neuroprotective Compound Library | FDA-Approved Drug Library | Anti-Cancer Approved Drug Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library | Anti-Cancer Active Compound Library |
United States
