| Name | Inosine |
| Description | Inosine (NSC-20262), an endogenous purine nucleoside produced by the catabolism of adenosine, is an agonist of adenosine receptors A1R and A2AR. Inosine has anti-inflammatory, immunomodulatory, antinociceptive and neuroprotective effects. |
| In vitro | METHODS: Rat C6, DU-145, HaCaT, L6, and MCF7 cells were treated with Inosine (0-250 μM) for 48 hours, and MTT assay was used to detect the inhibition of cell growth.
RESULTS: Inosine did not inhibit the growth of C6, DU-145, HaCaT, L6 and MCF7 cells at 250 μM. [1] |
| In vivo | METHODS: To study the analgesic effect of Inosine, Inosine (1 mg/kg, 10 mg/kg, and 100 mg/kg) was injected intraperitoneally to mice 20 min before formalin treatment.
RESULTS: Inosine reduced formalin-induced leg withdrawal. [2] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : < 1 mg/mL (insoluble or slightly soluble)
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (18.64 mM), Sonication is recommended.
DMSO : 245 mg/mL (913.4 mM), Sonication is recommended.
H2O : 43 mg/mL (160.31 mM), Sonication is recommended.
|
| Keywords | XO | Parkinson's | P1 receptor | nucleoside | NSC-20262 | NSC20262 | neuroprotective | metabolite | metabolism | Inosine | INO-495 | INO495 | Inhibitor | inhibit | immunomodulatory | human | EndogenousMetabolite | Endogenous Metabolite | disease | antinociceptive | antihyperalgesic | antiallodynic | AdenosineReceptor | Adenosine Receptor | adenosine |
| Inhibitors Related | Sucrose | Aceglutamide | Nicotinamide riboside malate | DL-Lysine | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Ethyl linoleate | Malic acid | Glycerol | Thymidine | Corn starch | Gluconate Calcium |
| Related Compound Libraries | Traditional Chinese Medicine Monomer Library | Alkaloid Natural Product Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Microbial Natural Product Library | FDA-Approved Drug Library | Human Endogenous Metabolite Library | Bitter Compound library | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library | GPCR Compound Library | Ancient Chinese Classical Formulas Compound Library | Anti-Cancer Drug Library |
United States
