| Name | Inosine |
| Description | Inosine (NSC-20262) is a purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It has immunomodulatory, neuroprotective, and analgesic properties. |
| In vitro | Inosine has been shown to stimulate axonal growth in cell culture and promote corticospinal tract axons to sprout collateral branches after stroke, spinal cord injury and TBI in rodent models.[1] Inosine dose-dependently stimulates cAMP production mediated through the A2AR. Inosine dose-dependently induces A2AR-mediated ERK1/2 phosphorylation.[2] |
| In vivo | The reference for Inosine is 1 or 10 mg/kg, i.p. Preventive treatment with inosine inhibits the development and progression of EAE in C57Bl/6 mice. neuroinflammation and demyelinating processes are blocked by inosine treatment. Additionally, inosine consistently inhibits IL-17 levels in peripheral lymphoid tissue, as well as IL-4 levels and A2AR up-regulation in the spinal cord, likely, through an ERK1-independent pathway. [3] inosine acting through adenosine receptors (ARs) exerts a wide range of anti-inflammatory and immunomodulatory effects in vivo. [2] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | Ethanol : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 55 mg/mL (205.05 mM), Sonication is recommended.
H2O : 43 mg/mL (160.31 mM), Sonication is recommended.
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| Keywords | XO | Parkinson's | P1 receptor | nucleoside | NSC-20262 | NSC20262 | neuroprotective | metabolite | metabolism | Inosine | INO-495 | INO495 | Inhibitor | inhibit | immunomodulatory | human | EndogenousMetabolite | Endogenous Metabolite | disease | antinociceptive | antihyperalgesic | antiallodynic | AdenosineReceptor | Adenosine Receptor | adenosine |
| Inhibitors Related | Sucrose | Daidzein | Guanidine hydrochloride | Fumaric acid | Ferulic Acid | L-Methionine | Oleamide | Glycerol | Thymidine | Naringin | L-Ascorbic acid sodium salt | 3-Indoleacetic acid |
| Related Compound Libraries | Membrane Protein-targeted Compound Library | Miao medicine Compound Library | Anti-Viral Compound Library | Neuroprotective Compound Library | FDA-Approved Drug Library | Anti-Cancer Approved Drug Library | Anti-Aging Compound Library | Anti-infective Natural Product Library | Bioactive Compounds Library Max | GPCR Compound Library | Ancient Chinese Classical Formulas Compound Library | Food as Medicine Compound Library |
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