| Name | Ionomycin calcium |
| Description | Ionomycin calcium (SQ23377 calcium) is an effective and selective calcium ionophore, demonstrating high specificity for divalent cations (Ca>Mg>Sr=Ba). |
| In vitro | METHODS: N1E-115 cells were treated with Ionomycin calcium (0.2-10 µM) for 3-24 h. Cell viability was determined by trypan blue dye exclusion assay.
RESULTS: Ionomycin calcium induced cell death in a concentration- and time-dependent manner. [1]
METHODS: Fura-2-loaded mouse cerebellar astrocytes were treated with Ionomycin calcium (0.1-10 µM) for 35 min, and cell membrane Ca(2+) concentration was monitored by changes in the Fura-2 340/380 ratio.
RESULTS: With Ionomycin calcium concentrations <1 µM, Ca(2+) declined slowly after an initial peak and reached a significantly lower level after 35 min. The peak Ca(2+) was maintained at a plateau stage with 2 µM Ionomycin calcium. Ionomycin calcium Ca(2+) at concentrations >2 µM was significantly higher than the initial peak after 35 min. [2] |
| In vivo | METHODS: To investigate the mechanism of demyelination induced in vivo, Ionomycin calcium (2-50 µM, 0.5 µL) was dorsal column injected into SD rats.
RESULTS: Ionomycin calcium-injected rats showed varying degrees of lesions observed on days 1-21, including areas of localized edema, a few scattered demyelinated axons, and larger lesions containing up to 200 demyelinated or degenerated axons. [3] |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween-80+45% Saline : 0.5 mg/mL (0.67 mM), Sonication is recommended.
DMSO : 9 mg/mL (12.05 mM), Sonication is recommended.
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| Keywords | SQ-23377 | SQ23377 | SQ 23377 | Protein kinase C | PKC | ionophore | Ionomycin calcium | Ionomycin | Inhibitor | inhibit | exosome | cleavage | CalciumChannel | Calcium ionophore | Calcium Channel | calcium | Ca2+ channels | Ca channels | Bacterial | Apoptosis | Antibiotic |
| Inhibitors Related | Neomycin sulfate | Aceglutamide | 2,4,6-Tri-tert-butylphenol | Adipic dihydrazide | D(+)-Raffinose pentahydrate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Formamide | Hyaluronic acid sodium (MW 20 kDa) | Dimethyl sulfoxide | Sodium diacetate | Sodium bicarbonate |
United States
