Ioversol Impurity 22;122731-74-2
WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com
Product Code：L066022
English Name：Ioversol Impurity 22
English Alias：3-amino-5-((2,3-dihydroxypropyl)carbamoyl)benzoic acid
CAS No.：122731-74-2
Molecular Formula：C₁₁H₁₄N₂O₅
Molecular Weight：254.24
High-Purity Reference Standard：Confirmed by HPLC (≥99.0%), NMR (1H, 13C), HRMS, and elemental analysis, suitable for Ioversol impurity analysis and quality control.
Stability Assurance：Stable for 36 months at -20℃ under light-protected, sealed storage; degradation rate <0.3% in methanol-water mixture within 6 months.
Quality Control Testing：Used for UPLC-MS/MS detection of Impurity 22 in Ioversol API and formulations, controlling content to meet ICH Q3A standards (single impurity limit ≤0.1%).
Process Optimization Research：Monitors impurity formation during Ioversol synthesis, reducing generation by >35% by adjusting amination temperature (e.g., 60-70℃) and pH.
Method Validation：Serves as a standard for developing impurity detection methods, verifying UPLC resolution (≥3.0) and LOD (0.01 ng/mL).
Ioversol, a non-ionic iodine contrast agent widely used in CT imaging, enhances tissue contrast by regulating blood osmotic pressure. Impurity 22, a process-related impurity in Ioversol synthesis, may originate from nitro reduction or carbamoylation side reactions. Its amino, amide, and hydroxyl groups may affect drug water solubility, osmotic regulation, and safety. Strict impurity control for medical imaging contrast agents is critical to patient safety, making research on this impurity essential for ensuring drug quality.
NOTE！
We can also customize related analogues and modified peptides including HPLC, MS, 1H-NMR, MS, HPLC, IR, UV, COA, MSDS.
This product is intended for laboratory use only!
WhatsAPP: +86 17386083646
E-mail: anna@molcoo.com
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