| Name | iRGD peptide |
| Description | iRGD peptide (c(CRGDKGPDC)) is a 9-amino acid cyclic peptide (sequence: CRGDKGPDC) and a molecular mimicry agent that was originally identified in an in vivo screening of phage display libraries in tumor-bearing mice. |
| In vitro | iRGD peptide-mediated tumor penetration involves a three-step process: initial binding to αv-integrins present on tumor vasculature or cells, the revelation of a C-terminal motif capable of binding to neuropilin-1 (NRP-1) through proteolysis, and subsequent cell internalization. Incorporation of the iRGD peptide into the ICOVIR15K fiber's C terminus specifically improves binding and internalization in MCF7 cells, known to express NRP-1 and integrins, without affecting the virus's ability to infect and replicate[1]. Alone, the iRGD peptide does not significantly impact gastric cancer cells. However, when combined with 5-FU, it notably enhances the chemotherapy's efficacy against gastric cancer cells via NRP1, at a concentration of 0.3 μmol/mL[2]. |
| In vivo | iRGD inserted in the oncolytic adenovirus ICOVIR15K (ICOVIR15K-iRGD) enhances early adenovirus dissemination through the tumor mass and elevates the antitumor effect in mice[1]. In vivo, iRGD did not alter the normal organ transduction pattern, with liver and spleen as main targeted organs. iRGD (4 mmol/kg, i.v.) combined with 5-FU significantly suppresses tumor growth in nude mice bearing human gastric cancer cells[2]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : Insoluble
H2O : 10 mM, Sonication is recommended.
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| Keywords | iRGD peptide | Integrin | Inhibitor | inhibit |
| Inhibitors Related | K34c hydrochloride | Cucurbitacin B | Tirofiban hydrochloride monohydrate | (R)-Leucic acid | Lifitegrast | Cyclo(-RGDfK) | ADH-503 | Elsibucol | CLT-28643 | Bestatin hydrochloride | Gantofiban | 2-hydroxy Flutamide |
| Related Compound Libraries | Cysteine Covalent Library | Macrocyclic Compound Library | Cyclic Peptide Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | ReFRAME Related Library | Peptide Compound Library | NO PAINS Compound Library | Bioactive Compounds Library Max | Covalent Inhibitor Library | Anti-Cancer Compound Library | Anti-Cancer Active Compound Library |
United States
