| Name | Isoastilbin |
| Description | Isoastilbin is a dihydroflavonol glycoside compound found in Rhizoma Smilacis glabrae and Astragalus membranaceus. Isoastilbin inhibits glucosyltransferase (GTase) with an IC50 value of 54.3 μg/mL and possesses anti-acne and tyrosinase inhibition properties. Additionally, isoastilbin demonstrates neuroprotective, antioxidation, antimicrobial, and anti-apoptotic properties, indicating potential for Alzheimer's disease research. |
| In vitro | The crude extracts were assayed for antimicrobial activities against Streptococcus sobrinus and for glucosyltransferase (GTase) inhibition. Fourteen extracts inhibited the growth of S. sobrinus by more than 50% and six extracts inhibited GTase activity by more than 50% at a concentration of 100 μg/ml. Koompassia malaccensis (kempas) extracts showed 90% depression of S. sobrinus growth and 80% inhibition of GTase activity at a concentration of 100 μg/ml. Kempas crude extracts were subjected to column chromatography using Sephadex LH-20 and then preparative high-performance liquid chromatography to isolate four compounds A, B, C, and D. These compounds were identified as taxifolin and the flavanonol rhamnoside isomers neoastilbin, astilbin, and Isoastilbin, respectively, from 1H and 13C nuclear magnetic resonance (NMR) spectra and other two-dimensional NMR techniques (COSY, HMBC, and HMQC). Each compound depressed the growth of S. sobrinus over a concentration range of 9.3242.7 μg/ml and showed GTase inhibitory activity with IC50 values in the range 27.4-57.3 μg/ml[1] |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (2.22 mM), Sonication is recommended.
DMSO : 25 mg/mL (55.51 mM), Sonication is recommended.
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| Keywords | Tyrosinase | neuroprotective | Isoastilbin | Inhibitor | inhibit | glycoside | disease | dihydroflavonol | Bacterial | Antioxidation | antimicrobial | Anti-infection | Antiinfection | Antifection | anti-apoptotic | Alzheimer's |
| Inhibitors Related | Neomycin sulfate | Adipic dihydrazide | Levulinic acid | D(+)-Raffinose pentahydrate | Sulfamethoxazole sodium | Terbinafine hydrochloride | Doxycycline | Ethyl linoleate | Hyaluronic acid sodium (MW 20 kDa) | Dimethyl sulfoxide | Sodium diacetate | Sodium bicarbonate |
| Related Compound Libraries | Polyphenolic Natural Product Library | Flavonoid Natural Product Library | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | Traditional Chinese Medicine Monomer Library | Selected Plant-Sourced Compound Library | Miao medicine Compound Library | Saccharide and Glycoside Natural Product Library | Inhibitor Library | Anti-infective Natural Product Library | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library | Food as Medicine Compound Library |
United States
