| Name | Isoborneol |
| Description | Isoborneol (DL-Isoborneol) is a monoterpene alcohol, with neuroprotective and antiviral activities |
| In vitro | Isoborneol, a monoterpene and a component of several plant essential oils, showed dual viricidal activity against herpes simplex virus 1 (HSV-1).?First, it inactivated HSV-1 by almost 4 log10 values within 30 min of exposure, and second, isoborneol at a concentration of 0.06% completely inhibited viral replication, without affecting viral adsorption.?Isoborneol did not exhibit significant cytotoxicity at concentrations ranging between 0.016% and 0.08% when tested against human and monkey cell lines.?Isoborneol specifically inhibited glycosylation of viral polypeptides based on the following data:?(1) the mature fully glycosylated forms of two viral glycoproteins gB and gD were not detected when the virus was replicated in the presence of isoborneol, (2) no major changes were observed in the glycosylation pattern of cellular polypeptides between untreated and isoborneol treated Vero cells, (3) isoborneol did not affect the glycosylation of gB produced from a copy of the gB gene resident in the cellular genome, and (4) other monoterpenes such as 1,8-cineole and borneol,?a stereoisomer of isoborneol, did not inhibit HSV-1 glycosylation[1]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 9 mg/mL (58.35 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (6.48 mM), Sonication is recommended.
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| Keywords | SH-SY5Y | ROS | plants | nervous | Isoborneol | HSV-1 | HSV | (±)-Isoborneol |
| Inhibitors Related | Levamisole hydrochloride | Inosine pranobex | Adipic acid | L-Lysine | 2-Deoxy-D-glucose | Oxyresveratrol | Vidarabine | N-Lauroylsarcosine | Acyclovir sodium | Acyclovir | Cytarabine | Trigonelline chloride |
| Related Compound Libraries | Terpene Natural Product Library | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Anti-Viral Compound Library | Neuroprotective Compound Library | Inhibitor Library | Natural Product Library for HTS | Flavor Natural Product library | Anti-infective Natural Product Library | Anti-Aging Compound Library | Ancient Chinese Classical Formulas Compound Library | Food as Medicine Compound Library |
United States
