| Name | Isoliquiritigenin |
| Description | Isoliquiritigenin (ISL) is a flavonoid natural product that inhibits influenza virus replication (EC50=24.7 μM) and aldose reductase activity (IC50=320 nM). Isoliquiritigenin has antitumor activity. |
| In vitro | METHODS: Normal human hepatocyte cell line LO2 and HCC cell line Hep3B were treated with Isoliquiritigenin (30-60 µM) for 24-72 h. Cell viability was measured by MTT assay.
RESULTS: Isoliquiritigenin showed significant cytotoxicity against Hep3B cells with an IC50 of 42.84±2.01 µM at 48 h. This effect was concentration and time dependent. However, at the same Isoliquiritigenin stimulation intensity, the survival of LO2 cells was significantly less affected with an IC50 >60 µM.[1]
METHODS: Human colorectal cancer cells HCT-116 were treated with Isoliquiritigenin (20 µM) for 24 h. Apoptosis was detected by Flow cytometry.
RESULTS: Treatment of HCT-116 cells with Isoliquiritigenin resulted in a significant increase in apoptosis (17.26%) in the treated group compared to the NC group (7.37%). [2] |
| In vivo | METHODS: To assay anti-tumor activity in vivo, Isoliquiritigenin (50 mg/kg) was injected intraperitoneally into BALB/c-nu/nu mice bearing Hep3B xenografts once daily for three weeks.
RESULTS: Isoliquiritigenin-treated mice had reduced tumor burden in terms of mean tumor size or xenograft weight. [1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5.1 mg/mL (19.9 mM), suspension.In vivo: Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately.
DMSO : 60 mg/mL (234.15 mM), Sonication is recommended.
Ethanol : 22 mg/mL (85.85 mM), Sonication is recommended.
H2O : < 1 mg/mL (insoluble or slightly soluble)
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| Keywords | SJ-000286237 | SJ000286237 | SJ 000286237 | Isoliquiritigenin | InfluenzaVirus | Influenza Virus | GU-17 | GU 17 | Autophagy | Apoptosis | Aldose Reductase | Aldose reductase |
| Inhibitors Related | Stavudine | Sodium 4-phenylbutyrate | L-Ascorbic acid | Hydroxychloroquine | Guanidine hydrochloride | L-Glutamic acid | Tributyrin | Valproic Acid | Paeonol | Naringin | L-Ascorbic acid sodium salt | Gefitinib |
| Related Compound Libraries | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Flavor Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Drug Repurposing Compound Library | Miao medicine Compound Library | Anti-Viral Compound Library | Bitter Compound library | Anti-infective Natural Product Library | Bioactive Compounds Library Max | Ancient Chinese Classical Formulas Compound Library | Anti-Cancer Drug Library |
United States
