| Name | Isolithocholic Acid |
| Description | Isolithocholic Acid (3-Epilithocholic acid) (β-Lithocholic acid) is an isomer of Lithocholic acid. Isolithocholic Acid, a bile acid, is formed by microbial metabolism of Lithocholic acid or Lithocholic acid 3α-sulfate. |
| In vitro | Isolithocholic Acid at a concentration of 0.01% does not inhibit the spore germination and outgrowth in CF5 and M120 strains, but at a higher concentration of 0.1%, it significantly inhibits these processes. At a much lower concentration (0.00003%), it prevents the growth of CD196, M68, CF5, 630, and BI9 strains, while also substantially reducing toxin activity in CF5, BI9, M120, and 630 strains. Furthermore, a slightly higher concentration of Isolithocholic Acid (0.0003%) results in a significant decrease in toxin activity across all strains, with the exception of R20291 and M120[3]. |
| In vivo | Fecal Isolithocholic Acid levels significantly decrease starting from day 28 in the high fat diet (HFD) group when compared to rats on a normal diet[4]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (2.66 mM), Sonication is recommended.
Chloroform : Slightly soluble
Ethanol : Slightly soluble
Methanol : Slightly soluble
DMSO : 13.51 mg/mL (35.88 mM), Sonication is recommended.
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| Keywords | Isolithocholic Acid | EndogenousMetabolite | Endogenous Metabolite | b-Lithocholic acid | beta-Lithocholic acid | 3b-Hydroxy-5b-cholanic acid | 3beta-Hydroxy-5beta-cholanic acid |
| Inhibitors Related | Sucrose | Aceglutamide | Nicotinamide riboside malate | DL-Lysine | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Malic acid | Formamide | Glycerol | Thymidine | Corn starch | Gluconate Calcium |
| Related Compound Libraries | Food Sourced Compound Library | Bioactive Compound Library | Natural Product Library for HTS | Human Endogenous Metabolite Compound Library Plus | Bioactive Compounds Library Max | Bioactive Lipid Compound Library | Gut Microbial Metabolite Library | Human Metabolite Library | Bile Acids Library |
United States
