| Name | Isorhamnetin-3-O-glucoside |
| Description | Isorhamnetin-3-O-glucoside (Isorhamnetin-3-O-beta-D-Glucoside) inhibits the activity of alpha-glucosidase from rat intestine; it exhibits a potent rat lens aldose reductase (RLAR) inhibition in vitro, its IC(50) being 1.4 microM and has inhibitory effects of sorbitol accumulation, suggests that it is a leading compound for further study as a new drug for the prevention and/or treatment of diabetes and its complications. |
| In vitro | The inhibitory effects of compounds from Salicornia herbacea (Chenopodiaceae) on rat lens aldose reductase (RLAR) and sorbitol accumulation in streptozotocin-induced diabetic rat tissues were investigated. METHODS AND RESULTS:The various fractions from the MeOH extract of S. herbacea were tested for their effects on RLAR in vitro. Among them, the EtOAc fraction was found to exhibit a potent RLAR inhibition (IC(50)=0.75 microg/ml), from which an active principle as a potent AR inhibitor was isolated and its chemical structure was elucidated as Isorhamnetin-3-O-beta-D-Glucoside (1) by spectral analysis. Compound 1 exhibited a potent RLAR inhibition in vitro, its IC(50) being 1.4 microM. Compound 1, when administered orally at 25 mg/kg in streptozotocin (STZ)-induced diabetic rats, caused not only a significant inhibition of serum glucose concentration but also sorbitol accumulation in the lenses, red blood cells (RBC), and sciatic nerves. CONCLUSIONS:These results indicate that compound 1 from S. herbacea is a leading compound for further study as a new drug for the prevention and/or treatment of diabetes and its complications. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5.00 mg/mL (10.45 mM), Sonication is recommended.
DMSO : 250.00 mg/mL (522.58 mM), Sonication is recommended.
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| Keywords | RLAR | Isorhamnetin-3-O-β-D-Glucoside | Isorhamnetin-3-O-glucoside | Isorhamnetin3Oglucoside | Isorhamnetin-3-O-b-D-Glucoside | Isorhamnetin 3 O glucoside | Inhibitor | inhibit | IL Receptor |
| Inhibitors Related | Aceglutamide | Musk ketone | Urea | Gum arabic | Myricetin | Hyaluronic acid | Lactose | Ethyl linoleate | Methyl eugenol | Gluconate Calcium | Daraxonrasib | 2,3-Butanediol |
| Related Compound Libraries | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Rare Natural Product Library | Selected Plant-Sourced Compound Library | Natural Product Library | Miao medicine Compound Library | Saccharide and Glycoside Natural Product Library | Inhibitor Library | Natural Product Library for HTS | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Ancient Chinese Classical Formulas Compound Library |
United States
