| Name | Isradipine |
| Description | Isradipine (PN 200-110) is a dihydropyridine calcium channel blocker with antihypertensive and vasodilator activities. Isradipine blocks calcium entry through calcium ion channels in coronary and peripheral vascular smooth muscle, dilating coronary arteries and peripheral arterioles. This action increases oxygen delivery by enhancing blood flow and decreases oxygen requirements by reducing total peripheral resistance. |
| In vitro | In vivo oxygen uptake (I50 = 31.1 mM) and growth incubation (I50 = 20.8 mM) assays showed that Isradipine was the most effective derivative. At micromolar concentrations, Isradipine inhibited oxygen consumption and growth incubation of the short-membrane form of Trypanosoma cruzi strain Tulahuen. |
| In vivo | In vivo oxygen uptake (I50 = 31.1 mM) and growth incubation (I50 = 20.8 mM) assays showed that Isradipine was the most effective derivative. At micromolar concentrations, Isradipine inhibited oxygen consumption and growth incubation of the short-membrane form of Trypanosoma cruzi strain Tulahuen. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : 7.4 mg/mL (19.93 mM), Sonication is recommended.
DMSO : 250 mg/mL (673.15 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (5.39 mM), Sonication is recommended.
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| Keywords | vasodilator | selective peripheral | powerful | peripheral | Parkinson's | neuroprotective | L-type | Isradipine | Inhibitor | inhibit | dihydropyridine | circulation | channel | CalciumChannel | Calcium Channel | calcium | Ca2+ channels | Ca channels | Autophagy |
| Inhibitors Related | Stavudine | Aceglutamide | Hemin | 2,4,6-Tri-tert-butylphenol | Tamoxifen | Cysteamine hydrochloride | Guanidine hydrochloride | Hydroxychloroquine | Paeonol | Naringin | Alginic acid | Sildenafil citrate |
| Related Compound Libraries | Failed Clinical Trials Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Neuroprotective Compound Library | FDA-Approved Drug Library | Anti-Cancer Approved Drug Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library |
United States
