| Name | ISX-9 |
| Description | ISX-9 (Isoxazole 9) is essential for activating neuron-specific genes and serves as a neurogenesis inducer. |
| Cell Research | Cells are treated with different concentrations of Isx-9 (0, 6.25, 12.5, 25, or 50 μM), and 2 days later, cell numbers are counted in a blinded manner to evaluate the effects of Isx-9 on the proliferation/survival of four types of progenitor/precursor cells.(Only for Reference) |
| In vitro | In NSPCs, isoxazole 9 increases cell number, and promotes cell differentiation. In OPCs, isoxazole 9 induces cell damage. In outgrowth EPCs, isoxazole 9 decreases tube formation without effect on early EPCs. [1] |
| In vivo | In mice, isoxazole 9 (20 mg/kg, i.p.) crosses the BBB and increases proliferation of neuroblasts and neurogenesis via Mef2-specific mechanisms in the hippocampal SGZ. Isoxazole 9 (20 mg/kg, i.p.) also increases differentiation and dendritic complexity of immature neurons and improves memory. In MWM, isoxazole 9 improves spatial memory. [2] |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : 11 mg/mL (46.95 mM), Sonication is recommended.
DMSO : 85 mg/mL (362.83 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (8.54 mM), Sonication is recommended.
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| Keywords | βcatenin | Wnt/β-catenin | Wnt/betacatenin | Wnt/b-catenin | Wnt | NMDA | neuroD | Mef2 | ISX-9 | ISX9 | ISX 9 | Isoxazole-9 | Isoxazole9 | Inhibitor | inhibit | CalciumChannel | Calcium Channel | Ca2+ channels | Ca2+ | Ca channels | beta-catenin | betacatenin | bcatenin |
| Inhibitors Related | Quadrol | Tricaine methanesulfonate | 2,4,6-Tri-tert-butylphenol | Urea | Chlorocresol | L-Ascorbic acid | Neohesperidin | Ethyl linoleate | L-Ascorbic acid sodium salt | 2-Nitrobenzoic acid | Magnesium Chloride Hexahydrate | Magnesium sulfate |
| Related Compound Libraries | Anti-Pancreatic Cancer Compound Library | Pain-Related Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Anti-Obesity Compound Library | Anti-Cancer Metabolism Compound Library | Calcium Channel Compound Library | Neuroprotective Compound Library | Bioactive Compounds Library Max | Cytoskeletal Signaling Pathway Compound Library | Ion Channel Targeted Library | Neuronal Differentiation Compound Library |
United States
