Product Brief: 6-Methoxy-3-pyridinecarboxamide (JBSNF-000088) | CAS: 7150-23-4
1. Product Identification
• CAS Number: 7150-23-4
• IUPAC Name: 6-Methoxynicotinamide
• Synonyms: 6-Methoxy-3-pyridinecarboxamide; JBSNF-000088
• Molecular Formula: C₇H₈N₂O₂
• Molecular Weight: 152.15 g/mol
• Chemical Structure: SMILES: O=C(N)C1=CN=C(OC)C=C1
• Physical Appearance: Off-White to Pale Beige Solid Powder
2. Key Properties
Parameter | Specification |
Melting Point | 178-180°C |
Boiling Point | 301.6±22.0 °C (Predicted) |
Density | 1.213±0.06 g/cm³ (Predicted) |
pKa | 15.17±0.50 (Predicted) |
Solubility | Slightly soluble in DMSO/Methanol; Soluble in DMSO (for formulation) |
Purity | ≥98% (HPLC, COA provided per batch) |
Heavy Metal Content | ≤10 ppm |
3. Biological Activity & Applications
A potent inhibitor of Nicotinamide N-methyltransferase (NNMT) , with:
• IC₅₀ values: 1.8 µM (hNNMT), 2.8 µM (mkNNMT), 5.0 µM (mNNMT)
• In vitro activity: IC₅₀ = 1.6 µM (U2OS cells), 6.3 µM (differentiated 3T3L1 cells)
• In vivo efficacy (HFD-induced obese mice):
◦ Significant body weight reduction
◦ Improved insulin sensitivity & normalized glucose tolerance
◦ Reduced fed blood glucose (day 21)
• Pharmacokinetics: Oral bioavailability ~40%; Tmax = 0.5 hours; Short half-life (0.4-0.5 hours)
Primary Applications:
• Drug discovery for metabolic disorders (obesity, type 2 diabetes)
• Research tool for NNMT-related pathways
• Intermediate in pharmaceutical synthesis
4. Quality & Supply Assurance
• Batch Consistency: Strict process control ensures uniform quality across productions
• Documentation: COA (Certificate of Analysis) and MSDS provided for each batch
• Inventory: Ready-to-ship stock (100mg, 500mg, 1g, 5g sizes)
• Sample Policy: 10-50g samples available for pre-purchase testing
• Pricing: Tiered pricing based on order volume; long-term partner discounts
5. Handling & Storage
• Storage Conditions:
◦ Short-term (days-weeks): 0-4°C, dry/dark
◦ Long-term (months-years): -20°C freezer
• Transport: Non-hazardous chemical; ambient temperature shipping
• Safety Precautions:
◦ Wear protective gloves, goggles, and dust mask
◦ Avoid contact with strong oxidizers, acids, or bases
◦ Work in well-ventilated areas to prevent dust inhalation
• Waste Disposal: Comply with local environmental regulations
6. Compliance
• Customs Code: 2933399990 (China); 2934.99.9001 (International)
• Legal Note: For research & manufacturing use only; not for human consumption. Avoid sale to patent-protected regions
China
