| Name | JHU37160 |
| Description | JHU37160 (JHU 37160) is a Designer Receptors Exclusively Activated by Designer Drug (DREADD) agonist with Ki of 1.9 nM and 3.6 nM for human muscarinic acetylcholine M3 receptors (hM3Dq) and hM4Di in vitro, respectively. And EC50 values are 18.5 nM and 0.2 nM for hM3Dq and hM4Di in fluorescent and BRET-based assays in HEK-293 cells, respectively. |
| In vitro | JHU 37160 is a potent agonist of DREADD with high potency and efficacy in fluorescent and BRET-based assays in HEK-293 cells, whereas no responses are observed in untransfected HEK-293 cells |
| In vivo | JHU 37160 exhibits high in vivo DREADD potency. It exhibits selective [3H]clozapine displacement from DREADDs in brain tissue from WT and D1-DREADD mice |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : 72 mg/mL (200.65 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (5.57 mM), Sonication is recommended. DMSO : 72 mg/mL (200.65 mM), Sonication is recommended.
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| Keywords | Muscarinic acetylcholine receptor | mAChR | M3 mAChR | JHU-37160 | JHU37160 | Inhibitor | inhibit | hM4Di | hM3Dq | DREADD | Clozapine |
| Inhibitors Related | Adiphenine hydrochloride | Levamisole hydrochloride | Ethyl (triphenylphosphoranylidene) acetate | Urethane | Hexamethonium Bromide | Ribavirin | Adenine | Mitotane | Choline chloride | Propoxur | N,N-Dicyclohexylcarbodiimide | Arecoline |
| Related Compound Libraries | Target-Focused Phenotypic Screening Library | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Neuronal Signaling Compound Library | Anti-Alzheimer's Disease Compound Library | Membrane Protein-targeted Compound Library | Anti-Parkinson's Disease Compound Library | Neurotransmitter Receptor Compound Library | CNS-Penetrant Compound Library | NO PAINS Compound Library | Bioactive Compounds Library Max | Fluorochemical Library |