| Name | JMV 2959 hydrochloride (925238-89-7 free base) |
| Description | JMV 2959 hydrochloride (925238-89-7 free base) is a growth hormone secretagogue receptor type 1a (GHS-R1a) antagonist with an IC50 of 32±3 nM in LLC-PK1 cells. |
| In vitro | JMV 2959 does not induce any intracellular calcium mobilization by itself. The dissociation constant of the receptor/JMV 2959 complex is determined by the Schild method. This experiment reveals a dissociation constant Kb of 19±6 nM.JMV 2959 is a growth hormone secretagogue receptor type 1a (GHS-R1a) antagonist with an IC50 of 32 nM. |
| In vivo | Intraperitoneal (i.p.) administration of Ghrelin at doses of 0.033, 0.1, and 0.33 mg/kg does not significantly affect acoustic startle responses (ASR) or prepulse inhibition (PPI) in rats. Conversely, i.p. injection of JMV 2959 at 1, 3, and 6 mg/kg reduces ASR and enhances PPI in a dose-dependent manner. While JMV 2959 at a non-effective dose on its own prevents PPI deficits induced by Phencyclidine (PCP) at 2 mg/kg, pre-administration of the highest dose of Ghrelin does not alter PPI responses to a sub-threshold dose of PCP (0.75 mg/kg). |
| Storage | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween-80+45% Saline : 3.3 mg/mL (6.05 mM), Sonication is recommended.
DMSO : 250 mg/mL (458.65 mM), Sonication is recommended.
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| Keywords | JMV-2959 Hydrochloride | JMV2959 Hydrochloride | JMV 2959 hydrochloride (925238897 free base) | JMV 2959 hydrochloride (925238 89 7 free base) | JMV 2959 Hydrochloride | GHS-R1a, in LLC-PK1 cells | GHS-R1a | 925238-89-7 free base | 925238-89-7 |
| Inhibitors Related | Ibutamoren Mesylate | YIL 781 | AnaMorelin hydrochloride | Anamorelin | Ibutamoren | CJC-1295 acetate(863288-34-0 free base) | L-692429 | Obestatin (human) | Taurolithocholic Acid 3-sulfate sodium salt | Obestatin (rat) acetate | TM-N1324 | Cortistatin-8 acetate |
| Related Compound Libraries | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Inhibitor Library | NO PAINS Compound Library | Endocrinology-Hormone Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Compound Library |
United States
