| Name | JNJ-55308942 |
| Description | JNJ-55308942 is a selective and brain-penetrant antagonist of P2X7 functional with IC50s of 10 and 15 nM and Kis of 7.1 and 2.9 nM for hP2X7 and rP2X7, respectively. |
| In vitro | JNJ-55308942 shows pKis of 8.1and 8.5 for recombinant hP2X7 and rP2X7. JNJ-55308942 attenuates IL-1β release in a concentration-dependent manner in human blood and in mouse blood and microglia[2]. |
| In vivo | JNJ-55308942 (5 mg/kg; p.o.) shows the F of 81%, Vss of 1.7 L/kg, CL of 1.7 L/kg, Cmax of 3.7 mL min/kg, and AUC of 1747 ng/mL[1]. In male C57/BL6J mice, JNJ-55308942 (30 mg/kg; p.o.) significantly attenuates the effect of LPS on FSC, CD45 surface expression, and CD11b surface expression. In a model of Bacillus Calmette-Guerin-induced depression, JNJ-55308942 (30 mg/kg; orally) reverses the BCG-induced deficits of sucrose preference and social interaction (ED50 = 0.07 mg/kg). The P2X7 antagonist (3 mg/kg, orally) blocks Bz-ATP-induced brain IL-1β release in conscious rats[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (9.4 mM), Sonication is recommended.
DMSO : 145 mg/mL (340.92 mM), Sonication is recommended.
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| Keywords | P2XReceptor | P2X7 | P2X Receptor | JNJ-55308942 | JNJ55308942 | JNJ 55308942 |
| Inhibitors Related | Gefapixant citrate | Eperisone hydrochloride | Aurintricarboxylic acid | Sodium metatungstate | NP-1815-PX | (E/Z)-Sivopixant | PSB-12062 | ATP disodium salt | Oxatomide | Ivermectin | Lappaconitine | Paroxetine |
| Related Compound Libraries | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Clinical Compound Library | Bioactive Compounds Library Max | Ion Channel Targeted Library | Anti-Cancer Compound Library | Anti-Cancer Drug Library |
United States
