| Name | K-80003 |
| Description | K-80003(TX-803) is a potent retinol-like X-receptor-alpha regulator that inhibits TRxrα-dependent Akt activation and tumor cell growth. |
| In vitro | In MCF-7 cells, cotreatment with K-80003 inhibits the TNFα-induced colocalization of tRXRα with p85α in the cytoplasm, leading to tRXRα nuclear localization. Western blotting reveals that the K-80003-stabilized tetrameric form of tRXRα is exclusively present in the nuclear fraction, while the tRXRα monomer is distributed in both nuclear and cytoplasmic fractions [1]. |
| In vivo | K-80003, a potent inhibitor of AKT activation by all-trans-retinoic acid, exhibits enhanced efficacy in inhibiting tRXRα-dependent AKT activation and tRXRα tumor growth in animals. K-80003 has high affinity for RXRα but lacks COX inhibitory activity [2]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2.5 mg/mL (7.43 mM), Sonication is recommended. DMSO : 60 mg/mL (178.36 mM), Sonication is recommended.
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| Keywords | TX803 | TX 803 | RXR | retinoid X receptor α | RAR | K-80003 | K80003 | K 80003 | Akt |
| Inhibitors Related | Aceglutamide | Musk ketone | Stearamide | Bisphenol A | Creatine monohydrate | Hyaluronic acid | Ethyl linoleate | Artemisinin | L-Valine | Methyl eugenol | Chloramphenicol | 2,3-Butanediol |
| Related Compound Libraries | Anti-Lung Cancer Compound Library | Anti-Colorectal Cancer Compound Library | Bioactive Compound Library | Kinase Inhibitor Library | Hematonosis Compound Library | Anti-Breast Cancer Compound Library | Anti-Ovarian Cancer Compound Library | Anti-Prostate Cancer Compound Library | Metabolism Compound Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max |