| Name | Kaempferol 3-neohesperidoside |
| Description | Kaempferol 3-neohesperidoside (Kaempferol 3-O-neohesperidoside), a flavonoid compound, exhibits an insulinomimetic effect on the rat soleus muscle. |
| In vitro | A stimulatory effect of Kaempferol 3-neohesperidoside ( 1) on glucose uptake (35% and 21%) was observed when the rat soleus muscle was incubated with 1 and 100 nM of this flavonoid glycoside, respectively. The concentration-response curve of insulin showed a stimulatory effect at 3.5 and 7.0 nM (42% and 50%) on glucose uptake when compared with the control group. The effect of Kaempferol 3-neohesperidoside on glucose uptake was completely nullified by pretreatment with LY294002, an inhibitor of phosphoinositide 3-kinase (PI3K), and RO318220, an inhibitor of protein kinase C (PKC). However, no significant change occurred on glucose uptake stimulated by Kaempferol 3-neohesperidoside when muscles were pretreated with PD98059, an inhibitor of mitogen-activated protein kinase (MEK), and cycloheximide, an inhibitor of protein synthesis. Kaempferol 3-neohesperidoside and insulin (7 nM) did not show a synergistic effect on glucose uptake. Additionally, 100 mg/kg of Kaempferol 3-neohesperidoside by oral gavage was able to increase glycogen content in the muscle[1] |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (3.36 mM), Sonication is recommended.
DMSO : 55 mg/mL (92.51 mM), Sonication is recommended.
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| Keywords | PI3K | MEK | Kaempferol 3-neohesperidoside | Kaempferol 3neohesperidoside | Kaempferol 3 neohesperidoside | Inhibitor | inhibit | GSK-3 | GSK3 |
| Inhibitors Related | Musk ketone | Myricetin | Creatine monohydrate | Hyaluronic acid | Ornithine-α-ketoglutarate | 4-Chloro-2'-bromoacetophenone | Ethyl linoleate | Sorbic acid | Isoprenaline hydrochloride | Methyl eugenol | L-Cysteine hydrochloride hydrate | Quercetin |
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United States
