| Name | Kisspeptin-10, human (TFA)(374675-21-5,FREE) |
| Description | Kisspeptin-10, human TFA is a potent vasoconstrictor and angiogenesis inhibitor. Kisspeptin-10, human TFA acts as a tumor metastasis suppressor via its receptor GPR54. Kisspeptin-10-GPR54 system plays an important role in embryonic kidney development. Kisspeptin-10/GPR54 signaling induces osteoblast differentiation via NFATc4-mediated BMP2 expression |
| In vitro | KP-10-treatment significantly increased the expression of osteogenic genes, including mRNA and protein levels of BMP2, in C3H10T1/2 cells.?Moreover, KP-10 induced BMP2-luc activity and increased phosphorylation of Smad1/5/9.?In addition, NFATc4 specifically mediated KP-10-induced BMP2 gene expression.?However, KP-10 treatment did not induce expression of the BMP2 and Runx2 genes in GPR54-/- cells.?To examine whether KP-10 induced secretion of BMP2 to the culture medium, we used the conditioned-medium (C.M) of KP-10 treated medium on C3H10T1/2 cells.?Dlx5 and Runx2 expressions were higher in GPR54-/- cells treated with C.M than in those treated with KP-10[1]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 4 mg/mL (2.82 mM), Sonication is recommended.
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| Keywords | Kisspeptin-10, human (TFA)(374675-21-5,FREE) | Kisspeptin10, human (TFA)(374675215,FREE) | Kisspeptin 10, human (TFA)(374675 21 5,FREE) | GPR54 |
| Inhibitors Related | Monomethyl fumarate | Pamoic acid disodium | Azathioprine | CRTh2 antagonist 2 | Fezagepras sodium | Benzyl nicotinate | 1-methoxycyclopropanecarboxylic acid | TUG-1375 | CAY10595 | TUG-424 | Timapiprant | Tricosanoic acid |
| Related Compound Libraries | Failed Clinical Trials Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Drug Repurposing Compound Library | Peptide Compound Library | Inhibitor Library | NO PAINS Compound Library | Bioactive Compounds Library Max | Fluorochemical Library | GPCR Compound Library | Anti-Cancer Active Compound Library | Anti-Cancer Drug Library |