| Name | Kurarinone |
| Description | Kurarinone is a flavonoid extracted from the shrub Sophora flavescens, which has anti-tumor, estrogenic and anti-inflammatory activities, and also has a strong inhibitory effect on immune responses. |
| In vitro | METHODS: To test the cytotoxicity of kurarinone on HMC3 cells, we treated HMC3 cells with different concentrations of kurarinone (10, 20, 40 or 80 μM) for 24 hours.
RESULTS HMC3 cell viability was reduced after treatment with 80 μM Kur.
METHODS: Two human small cell lung cancer (SCLC) cell lines H1688 and H146, and an immortalized bronchial epithelial cell line BEAS-2B were treated with different concentrations of kurarinone (3.125 ~ 50 μM), and the IC50 was determined.
RESULTS The IC50 values of kurarinone against H1688, H146 and BEAS-2B cells were 12.5±4.7, 30.4±5.1 and 55.8±4.9 μM respectively. [3] |
| In vivo | METHODS: Arthritis was reproduced in DBA/1 mice by inducing bovine type II collagen (CII) as a collagen-induced arthritis (CIA) model. After establishment of CIA, kurarinone (100 mg/kg/day) was administered orally from day 21 to day 42, and severity was determined based on symptom scoring scales and histopathology. ELISA and flow cytometry were used to detect the cytokine levels, anti-cii antibody levels, and T cell proliferation and lineage in the draining lymph nodes, respectively.
RESULTS kurarinone treatment reduced the severity of arthritis in CIA mice and reduced the levels of pro-inflammatory cytokines TNF-α, IL-6, IFN-γ and IL-17A in serum and foot tissue. [1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 235 mg/mL (535.91 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (4.56 mM), Sonication is recommended.
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| Keywords | TNF-α | STAT | NF-κB | NFκB | NF-kB | NFkB | Kurarinone | JAK | IκB | Inhibitor | inhibit | IKK | IkB/IKK | IkB | CD4(+) | Bcl-2 |
| Inhibitors Related | Kaolin | Flubendazole | Acetylcysteine | Gum arabic | Kojic acid | Fumaric acid | 1,8-Cineole | 1,4-Naphthoquinone | Tributyrin | Ethyl linoleate | N,N-Dimethylacetamide | Daraxonrasib |
| Related Compound Libraries | Polyphenolic Natural Product Library | Flavonoid Natural Product Library | Bioactive Compound Library | Tyrosine Kinase Inhibitor Library | Selected Plant-Sourced Compound Library | Kinase Inhibitor Library | Miao medicine Compound Library | Natural Product Library | Natural Product Library for HTS | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library |
United States
