| Name | L-692429 |
| Description | L-692429 (MK-0751) is a potent nonpeptidyl growth hormone secretagogue (GHS) agonist and benzolactam derivative, known for reversing glucocorticoid-induced inhibition of GH secretion. L-692429 exhibits high affinity for the G protein-coupled receptor and is useful in studying acromegaly and obesity. |
| In vitro | L-692429, a chemical compound, activates various cellular mechanisms, including intracellular calcium release, inositol phosphate (IP) turnover, cAMP-responsive element binding protein (CREB) activity, serum-responsive element activity, and bioluminescence resonance energy transfer (BRET) activity, with EC50 values of 26 nM, 47 nM, 60 nM, 63 nM, and 58 nM, respectively[2]. In experiments involving HeLa-T4 cells, those transiently expressing flag epitope-tagged growth hormone secretagogue (GHS) receptor and treated with L-692429 show a measurable increase in intracellular calcium, as detected by fluorometry using fluo-3/AM calcium indicator dye. This response is absent in untransfected HeLa-T4 cells, indicating the specificity of L-692429 for GHS receptor-expressing cells. Moreover, L-692429 treatment significantly enhances luciferase activity in these cells, suggesting that GHS receptor activation triggers the MAPK pathway[1]. |
| In vivo | In anesthetized Wistar rats, L-756867 dose-dependently suppresses GH secretion stimulated by L-692429 (100 μg/kg), with complete inhibition achieved at an intravenous dose of 100 μg/kg of L-756867[3]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (3.92 mM), Sonication is recommended.
DMSO : 40 mg/mL (78.49 mM), Sonication is recommended.
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| Keywords | MK0751 | MK 0751 | L-692429 | L692429 | L 692429 | Growth hormone secretagogue (GHS) | GHSR | G protein-coupled Bile Acid Receptor 1 |
| Inhibitors Related | Taurodeoxycholic acid | Ibutamoren Mesylate | Anamorelin | Ursodeoxycholic acid sodium | TC-G 1005 | Triamterene | Deoxycholic acid | Ursodeoxycholic acid | Deoxycholic acid sodium salt | Sodium taurodeoxycholate hydrate | Hyodeoxycholic acid | PEN (human) aceate |
| Related Compound Libraries | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Multi-Target Compound Library | Endocrinology-Hormone Compound Library | Bioactive Compounds Library Max | GPCR Compound Library |
United States
