| Name | L-Cysteinesulfinic acid |
| Description | L-Cysteinesulfinic acid is an endogenous neurotransmitter with agonistic effects on a variety of metabotropic glutamate receptors (mGluRs), including mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, with a pEC50 = 2.7 to 4.0. L- Cysteinesulfinic acid is a pld-coupled agonist of metabotropic excitatory amino acid (EAA) receptors. |
| In vitro | CHO cells expressing mGluR1, mGluR5, and mGluR8 were treated with L-Cysteinesulfinic acid (L-CSA) for 45 minutes at 37°C, and receptor activation was assessed by measuring [³H]-inositol phosphate accumulation. The results showed that L-CSA activated mGluR1 and mGluR5, inducing IP formation with lower potency than L-glutamate but with significant activity. In cells expressing mGluR2, mGluR4, and mGluR6, L-CSA inhibited forskolin-induced cAMP production, indicating activation of these Gi/o-coupled receptors via inhibition of adenylyl cyclase [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : 110 mg/mL (718.2 mM), Sonication is recommended.
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| Keywords | L-Cysteinesulfinic acid | LCysteinesulfinic acid | L Cysteinesulfinic acid | Human Endogenous Metabolite |
| Inhibitors Related | Sucrose | Aceglutamide | Nicotinamide riboside malate | DL-Lysine | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Formamide | Glycerol | Thymidine | Corn starch | Hyaluronic acid sodium (MW 20 kDa) | Gluconate Calcium |
| Related Compound Libraries | Bioactive Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Neurotransmitter Receptor Compound Library | Multi-Target Compound Library | Bioactive Compounds Library Max | Human Metabolite Library |
United States
