| Name | L-Glutamic acid monosodium salt |
| Description | L-Glutamic acid monosodium salt (MSG) (Monosodium glutamate) is an activator of mGlu1 receptor. |
| Cell Research | B cells are cultured with and with out increasing concentrations of MSG(1-100 mM) for 24 h. The number of early apoptotic cells and necrotic cells is determined using Annexin-V FITC/PI staining. (Only for Reference) |
| In vitro | Monosodium glutamate(MSG) induces apoptosis in human B cells. It has a more potent apoptotic effect in na?ve B cells compared to memory B cell population[3]. Low doses of L-monosodium glutamate promote neuronal growth and differentiation in vitro[4]. |
| In vivo | Daily L-Glutamic acid monosodium salt(MSG) dietary consumption reduces pancreatic β-cell mass and enhances hemorrhages and fibrosis, but does not affect glucose homeostasis. High dietary MSG intake may exert a negative effect on the pancreas and such effect might become functionally significant in the presence or susceptibility to diabetes or NaCl. Parenteral MSG causes various changes in pancreatic islets such as hypertrophy, hyperplasia, decrease in acinar cells, α-cells and somatostatin cells and increase in fibrosis[1]. MSG may have some deleterious effects on the testes of Wistar rats and by extension may contribute to the causes of male infertility[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : < 1 mg/mL (insoluble or slightly soluble)
H2O : 115 mg/mL (680.03 mM), Sonication is recommended.
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| Keywords | mGluR1 | LGlutamic acid monosodium salt | L-Glutamic acid monosodium | L-Glutamic acid | L Glutamic acid monosodium salt | Ionotropic glutamate receptors | Inhibitor | inhibit | iGluR | Ferroptosis | Endogenous Metabolite | Apoptosis |
| Inhibitors Related | Sucrose | Aceglutamide | Hemin | Nicotinamide riboside malate | DL-Lysine | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Malic acid | Glycerol | Thymidine | Corn starch | Gluconate Calcium |
| Related Compound Libraries | Apoptosis Compound Library | Pesticide Compound Library | Bioactive Compound Library | Approved Drug Library | Membrane Protein-targeted Compound Library | Selected Plant-Sourced Compound Library | Drug Repurposing Compound Library | Anti-Cancer Approved Drug Library | FDA-Approved Drug Library | Bioactive Compounds Library Max | Ion Channel Targeted Library | Anti-Cancer Drug Library |
United States
