L-γ-Glutamyl-S-nitroso-L-cysteinylglycine NEW

$2.20 100KG

$6.60 10KG

$8.80 1KG

Min. Order1KG
Purity99%
Cas No57564-91-7
Supply Abilityg-kg-tons
Update time2026-04-17

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

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China

Chemical Properties

Product Name	L-γ-Glutamyl-S-nitroso-L-cysteinylglycine
CAS No	57564-91-7
EC-No
Min. Order	1KG
Purity	99%
Supply Ability	g-kg-tons
Release date	2026/04/17

L-γ-Glutamyl-S-nitroso-L-cysteinylglycine

Modify Date: 2024-01-02 23:38:08

L-γ-Glutamyl-S-nitroso-L-cysteinylglycine structure	Common Name	L-γ-Glutamyl-S-nitroso-L-cysteinylglycine
	CAS Number	57564-91-7	Molecular Weight	336.322
	Density	1.7±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C10H16N4O7S	Melting Point	>170ºC (dec.)
	MSDS	ChineseUSA	Flash Point	N/A
	Symbol	GHS07	Signal Word	Warning

Purity		Quantity		Budget		Inquiry

Use of L-γ-Glutamyl-S-nitroso-L-cysteinylglycine

Nitrosoglutathione (GSNO), a exogenous NO donor and a substrate for rat alcohol dehydrogenase class III isoenzyme, inhibits cerebrovascular angiotensin II-dependent and -independent AT1 receptor responses[1][2][3][4].

Properties
Articles79
Spectrum

Name	S-nitrosoglutathione
Synonym	More Synonyms

Description	Nitrosoglutathione (GSNO), a exogenous NO donor and a substrate for rat alcohol dehydrogenase class III isoenzyme, inhibits cerebrovascular angiotensin II-dependent and -independent AT1 receptor responses[1][2][3][4].
Related Catalog	Research Areas >> Cardiovascular Disease Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Angiotensin Receptor
In Vitro	Nitrosoglutathione (GSNO, 250 μM) prevents 90% of the response to 0.1 μM 5-HT and 40% of the response to 1.0 μM 5-HT in rings treated with LY-83583, indicating an effect of GSNO that was independent of guanylate cyclase activity[5].
In Vivo	Nitrosoglutathione (GSNO, 8 mg/kg) significantly decreases systolic, diastolic, and mean arterial pressures in PE-induced rats from day 14 through day 20[3]. Nitrosoglutathione (GSNO, 0.2 and 0.6 mg/kg) significantly inhibits superoxide production and suppressed NF-κB activation, iNOS induction, and 3-nitrotyrosine expression, butup-regulates endothelial NOS expression in the flap vessels[4]. Animal Model: Male Lewis rats[4]. Dosage: 0.2 and 0.6 mg/kg. Administration: Slow intravenous injection via the opposite femoral vein into each rat. Result: Animals treated with 0.2 mg of GSNO per kilogram before reperfusion had an intermediate survival rate (40.2 ± 4.9%). Although 0.6 mg/kg of GSNO showed a better rescuing effect than 150 mg/kg of NAC, there was no significant difference between the groups.
References	[1]. Marie-Lynda Bouressam, et al. S-nitrosoglutathione inhibits cerebrovascular angiotensin II-dependent and -independent AT 1 receptor responses: A possible role of S-nitrosation. Br J Pharmacol. 2019 Jun;176(12):2049-2062. [2]. D E Jensen, et al. S-Nitrosoglutathione is a substrate for rat alcohol dehydrogenase class III isoenzyme. Biochem J. 1998 Apr 15;331 ( Pt 2)(Pt 2):659-68. [3]. Caneta Brown, et al. The effects of S-nitrosoglutathione and S-nitroso-N-acetyl-D, L-penicillamine in a rat model of pre-eclampsia. J Nat Sci Biol Med. 2013 Jul;4(2):330-5. [4]. Yur-Ren Kuo, et al. Nitrosoglutathione promotes flap survival via suppression of reperfusion injury-induced superoxide and inducible nitric oxide synthase induction. J Trauma. 2004 Nov;57(5):1025-31. [5]. Eva Nozik-Grayck, et al. Pulmonary vasoconstriction by serotonin is inhibited by S-nitrosoglutathione. Am J Physiol Lung Cell Mol Physiol. 2002 May;282(5):L1057-65.

Density	1.7±0.1 g/cm3
Melting Point	>170ºC (dec.)
Molecular Formula	C10H16N4O7S
Molecular Weight	336.322
Exact Mass	336.073975
PSA	213.55000
LogP	-0.26
Index of Refraction	1.656
Storage condition	−20°C

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