| Name | Lactupicrin |
| Description | Lactupicrin is a natural product discovered in chicory, exhibiting analgesic, sedative, antimalarial, and anti-atherosclerotic effects. It inhibits NF-κB activation and LDLR1 production, and demonstrates inhibitory activity against yeast alpha-glucosidase (IC50 = 14.71 µM). |
| In vitro | Lactupicrin (0.25-1 μM, 24 hours) attenuates cholesterol influx into low-grade inflammatory macrophages by targeting LOX-1 [2].
In inflammatory macrophages, Lactupicrin (0.625-40 μM, 24 hours) inhibits the activity of NF-κB within inflammatory macrophages [3].
In inflammatory macrophages, Lactupicrin (40 μM, 24 hours) suppresses the nuclear translocation process of p65 by downregulating cytoplasmic dynein-mediated transport of p65 [3].
Lactupicrin (50 μg/L, 48 hours) exhibits complete inhibitory effects on parasite growth [4].
Lactupicrin (10-1000 μM, 45 minutes) dose-dependently inhibits AChE activity [4]. |
| In vivo | Lactupicrin (15-30 mg/kg, intraperitoneal injection) exhibits analgesic activity and sedative properties in mice [1].
In ApoE-/- mice, Lactupicrin (1.2-120 mg/kg, oral administration, once daily for 12 weeks) exerts its anti-atherosclerotic effects by reducing LOX-1 in lipid rafts, thereby inhibiting macrophage foam cell formation [2].
In ApoE-/- mice, Lactupicrin (1.2-120 mg/kg, oral administration, once daily for 12 weeks) can suppress early atherosclerosis formation [3].
In ApoE-/- mice, Lactupicrin (1.2-120 mg/kg, oral administration, once daily for 12 weeks) dose-dependently reduces serum levels of IL-1β and TNF-α, but does not lower IL-6 levels [3]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 200 mg/mL (487.31 mM), Sonication is recommended.
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| Keywords | Lactupicrin | Antifection |
| Inhibitors Related | Gum arabic | Kojic acid | Hydroxychloroquine | Metronidazole | Avermectin B1a | 2-Amino-2-methyl-1-propanol | Doxycycline | 1,4-Naphthoquinone | Ethyl linoleate | Fenpyroximate | N,N-Dimethylacetamide | Methylene Blue trihydrate |
| Related Compound Libraries | NF-κB Signaling Compound Library | Terpene Natural Product Library | Anti-Parasitic Compound Library | Bioactive Compound Library | Lipid Metabolism Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Compound Library | Human Metabolite Library | Transcription Factor-Targeted Compound Library |
United States
