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ChemicalBook Product Catalog API Synthetic Anti-infective Drugs Antiviral drugs Lamivudine

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Lamivudine NEW

$53.00 50mg

$79.00 100mg

$189.00 500mg

Min. Order
Purity99.56%
Cas No134678-17-4
Supply Ability10g
Update time2025-04-27

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

VIP2Y

United States

United States

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Chemical Properties

Product Name	Lamivudine
CAS No	134678-17-4
EC-No
Min. Order
Purity	99.56%
Supply Ability	10g
Release date	2025/04/27

Product Introduction

Bioactivity

Name	Lamivudine
Description	Lamivudine (BCH-189) is a reverse transcriptase inhibitor and ZALCITABINE analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It is used to treat HIV disease.
In vivo	Lamivudine exhibits selective inhibitory activity against deoxycytidine kinase, an unusual substrate for the non-natural L-isomer of dNTPs preferred by HBV polymerase. The anti-HBV activity of PCV is attributed to the broad substrate specificity of deoxycytidine kinase and an unusual substrate preference of HBV polymerase for the non-natural L-conformation of dNTPs. The anti-HBV efficacy of PCV appears to rely on multiple factors, including optimal phosphorylation (sufficient for antiviral activity but not cytotoxicity), the extended intracellular half-life of PCV-TP, and the ability of PCV-TP to inhibit the initiation of HBV RT as well as its RT and DNA polymerase activities. Combined use of Lamivudine and Cidofovir synergistically inhibits replication of duck hepatitis B virus and is more effective in reducing the persistent covalently closed circular (CCC) DNA form of DHBV than when used separately. In PBMCs, Lamivudine inhibits HIV-1 p24 antigen production with ED50s ranging from 0.07 μM to 0.2 μM.
Storage	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility Information	DMSO : 55 mg/mL (239.9 mM), Sonication is recommended. Ethanol : < 1 mg/mL (insoluble or slightly soluble) H2O : 42 mg/mL (183.2 mM), Sonication is recommended.
Keywords	susceptible \| ReverseTranscriptase \| Reverse Transcriptase \| orally active \| Lamivudine \| Inhibitor \| inhibit \| Human immunodeficiency virus \| HIVProtease \| HIV Protease \| HIV neurodegeneration \| HIV \| Hepatitis B virus \| HBV \| CNS penetration,brain region \| BCH189 \| BCH 189
Inhibitors Related	Stavudine \| 5-Fluorouracil \| Inosine pranobex \| Emtricitabine \| Kaempferol \| Dolutegravir intermediate-1 \| Dextran sulfate sodium salt (MW 4500-5500) \| Dimethyl fumarate \| Chloroquine phosphate \| Valproic Acid \| Decanedioic acid \| Tenofovir
Related Compound Libraries	Bioactive Compound Library \| EMA Approved Drug Library \| Anti-Cancer Clinical Compound Library \| Anti-Viral Compound Library \| Drug Repurposing Compound Library \| Inhibitor Library \| FDA-Approved Drug Library \| Anti-Cancer Approved Drug Library \| Immunology/Inflammation Compound Library \| Bitter Compound library \| Bioactive Compounds Library Max \| Anti-Cancer Drug Library

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