| Name | Latrepirdine dihydrochloride |
| Description | Latrepirdine dihydrochloride (Dimebolin dihydrochloride) is an orally active, and neuroactive antagonist of multiple drug targets, including histamine receptors, GluR, and 5-HT receptors, used as an antihistamine drug. |
| In vitro | Latrepirdine increases succinate dehydrogenase activity (MTT-assay), mitochondrial membrane potential (DeltaPsim), and cellular ATP levels in primary mouse cortical neurons and human neuroblastoma cells (SH-SY5Y). Latrepirdine enhances mitochondrial function both in the absence and presence of stress and Dimebon-treated cells are partially protected to maintain cell viability. [1] Latrepirdine leads to enhanced mTOR- and Atg5-dependent autophagy in cultured mammalian cells. [2] latrepirdine stimulates MTOR- and ATG5-dependent autophagy, leading to the reduction of intracellular levels of APP metabolites, including Aβ in cultured cells. [3] Latrepirdine stimulates the degradation of α-syn in differentiated SH-SY5Y neurons, and in mouse brain following chronic administration, in parallel with elevation of the levels of markers of autophagic activity. [4] Latrepirdine increases intracellular ATP levels and glucose transporter 3 translocation to the plasma membrane in primary neuron. [5] |
| In vivo | Latrepirdine treatment of TgCRND8 transgenic mice is linked to improved learning behavior and reduced accumulation of Aβ42 and α-synuclein. [2] Latrepirdine administration results in increased levels of biomarkers associated with autophagy activation in the brains of TgCRND8 (APP K670M, N671L, V717F) or wild-type mice, and is also associated with behavioral improvement, reduced Aβ neuropathology, and prevention of autophagic failure in TgCRND8 mice. [3] |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 39.2 mg/mL (99.91 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween-80+45% Saline : 0.5 mg/mL (1.27 mM), Sonication is recommended.
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| Keywords | βAmyloid | β Amyloid | HistamineReceptor | Histamine Receptor | GluR | BetaAmyloid | Beta Amyloid | bAmyloid | b Amyloid | Autophagy | Amyloid-β | AdrenergicReceptor | Adrenergic Receptor | 5HTReceptor | 5-HT Receptor | 5HT Receptor |
| Inhibitors Related | Stavudine | Aceglutamide | Hemin | Tamoxifen | Cysteamine hydrochloride | Guanidine hydrochloride | Hydroxychloroquine | Enzalutamide | Paeonol | Naringin | Alginic acid | Sildenafil citrate |
| Related Compound Libraries | Failed Clinical Trials Compound Library | Anti-Neurodegenerative Disease Compound Library | Pain-Related Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Drug Library |
United States
