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ChemicalBook Product Catalog LC-MB12

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LC-MB12 NEW

$137.00 1mg

$342.00 5mg

$549.00 10mg

Min. Order
Purity99.16%
Cas No2828438-38-4
Supply Ability10g
Update time2026-04-13

TargetMol Chemicals Inc.

TargetMol Chemicals Inc.

VIP6Y

United States

United States

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Chemical Properties

Product Name	LC-MB12
CAS No	2828438-38-4
EC-No
Min. Order
Purity	99.16%
Supply Ability	10g
Release date	2026/04/13

Product Introduction

Bioactivity

Name	LC-MB12
Description	LC-MB12 is an orally active, selective and potent PROTAC FGFR2 complex that degrades FGFR2.LC-MB12 has antiproliferative and antitumor activity.LC-MB12 is used in the study of gastric cancer because of its inhibition of FGFR2 signaling.LC-MB12 has been shown to have antiproliferative and antitumor activity.LC-MB12 has been shown to have antiproliferative and antitumor activity.
In vitro	0.5-10000 nM LC-MB12, FGFR2 was degraded in KATO III in a time-dependent manner over 3-12 hours, DC50=11.8 nM. [1] 100 nM LC-MB12 treatment for 6 hours resulted in 77% degradation of FGFR2 in KATO III and 43% degradation in NCI-H1581. [1] 1-10000 nM LC-MB12 treatment for 72 h significantly inhibited the growth of KATO III, SNU-16, and NCI-H716 with IC50=29.1 nM (KATO III), IC50=3.7 nM (SNU-16), and IC50=3.2 nM (NCI-H716), respectively, and induced KATO III G0 /G1 phase block. [1]
In vivo	Oral administration of 20 mg/kg LC-MB12 was rapidly absorbed in mice (Cmax: 2.6 h) with oral bioavailability (F: 13%). Oral administration for 30 days was well tolerated and showed no significant hepatotoxicity or nephrotoxicity in mice. [1] 20 mg/kg/day LC-MB12 administered orally for 15 days inhibited tumor growth by 63.1% in the SNU-16 nude mouse xenograft model. [1]
Storage	Shipping with blue ice.
Solubility Information	DMSO : 120 mg/mL(133.37 mM), Sonication is recommended.
Keywords	PROTAC \| FGFR2
Inhibitors Related	Amlexanox \| Regorafenib monohydrate \| Nintedanib \| Ferulic Acid \| Nintedanib esylate \| Regorafenib \| Formononetin \| Lenvatinib mesylate \| Erdafitinib \| Vepdegestrant \| Lenvatinib \| Pazopanib
Related Compound Libraries	Osteogenesis Compound Library \| Anti-Lung Cancer Compound Library \| Bioactive Compound Library \| Kinase Inhibitor Library \| Tyrosine Kinase Inhibitor Library \| Post-Translational Modification Compound Library \| Bioactive Compounds Library Max \| Anti-Cancer Compound Library \| Anti-Cancer Active Compound Library

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