| Name | Leucomethylene blue mesylate |
| Description | Leucomethylene blue mesylate (TRx0237 mesylate) is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia. |
| In vitro | Leucomethylene blue is a second-generation tau protein aggregation inhibitor for the treatment of Alzheimer's disease (AD) and frontotemporal dementia. It is a purified forms of Methylene Blue, an old drug that predates the FDA and is being widely used in Africa for the treatment for malaria as well as for methemoglobinemia and other conditions[2]. An in vitro study showed the ability of Leucomethylene blue in disrupting PHFs(paired helical filaments) isolated from Alzheimer's Disease brain tissues at the concentration at 0.16 μM[1]. |
| In vivo | Leucomethylene blue dose-dependently rescues the learning impairment and restores behavioral flexibility in a spatial problem-solving water-maze task in L1 (minimum effective dose: 9 mg MT/kg for TRx0237) and correctes motor learning in L66 (effective doses: 4 mg MT/kg). It reduces the number of tau-reactive neurons, particularly in the hippocampus and entorhinal cortex in L1 and in a more widespread manner in L66[1]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : < 1 mg/mL (insoluble or slightly soluble)
H2O : 87 mg/mL (182.15 mM), Sonication is recommended.
DMSO : 88 mg/mL (184.25 mM), Sonication is recommended.
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| Keywords | β-amyloid peptide | βAmyloid | β Amyloid | TRx0237 Mesylate | TRx0237 (LMTX) Mesylate | TRx-0237 | TRx0237 | TRx 0237 | Tau aggregation | Tau | MicrotubuleAssociated | Microtubule Associated | Methylene blue leuco base Mesylate | Methylene blue leuco base | Leucomethylene blue Mesylate | Leucomethylene Blue | Inhibitor | inhibit | Disease | BetaAmyloid | Beta Amyloid | bAmyloid | b Amyloid | Aβ25-35 | Amyloid-β | Alzheimer's | aggregation | Abeta |
| Inhibitors Related | Flubendazole | Benzenesulfonamide | Deferoxamine Mesylate | HEPPS | Phytic acid sodium salt | Rutin | 10-Undecenoic acid | α-Cyclodextrin | 2,4-Di-tert-butylphenol | Methylene Blue trihydrate | Chlorzoxazone | Methyl tridecanoate |
| Related Compound Libraries | Failed Clinical Trials Compound Library | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Anti-Alzheimer's Disease Compound Library | Neuronal Signaling Compound Library | Drug Repurposing Compound Library | Microtubule-Targeted Compound Library | Inhibitor Library | NO PAINS Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Cytoskeletal Signaling Pathway Compound Library |
United States
