Introduce:
In recent years, the number of malignant tumors in our country is increasing year by year, chemotherapy is still the main means to treat malignant tumors. Chemotherapy will lead to the majority of patients with impaired immune function, causing serious infection and other complications. Therefore, it is of great significance to develop drugs to enhance immune function. Levamisole hydrochloride is often used as a deworming drug, but also has an immunomodulatory effect, which can effectively improve the immune function of patients.
Clinical application:
Levamisole can regulate immune function, mainly acting on T lymphocytes to induce early differentiation and maturation of T cells into functional T cells, thus promoting the normal function of T cells ht. It can also strengthen phagocytosis and chemotaxis of macrophages to improve the activity of natural killer cells, produce endogenous interferon, improve immune function and make them normal. Effectively prevent the progression of pneumonia, improve cough, lung sound and other symptoms. In addition, after the immune function of children is weakened, after taking levamisole hydrochloride, it can increase the content of total complement in the blood, especially increase the production of IgG and IgA, so as to improve the immune effect of the respiratory tract membrane, and play the role of virus resistance and bacterial infection. Levamisole can not only regulate immunity, but also restore immunity. Levamisole can show bidirectional regulation of humoral immune dysfunction, make it tend to normal development, and help hypocellular immune function return to normal.
Production method:
racemic tetramidazole (C11H12N2S, [5036-02-2]) was separated, alkali-separated and salted. The dibenzoyl-D-tartrate anhydride was boiled with water and hydrolyzed for 40min. The temperature is lowered to about 45℃, the pH is adjusted to 7.5 with sodium hydroxide solution, and racemic tetraimidazole is added. After half an hour of heat preservation, the temperature is lowered to 10℃, filtered and washed to obtain levamisole p-benzoyl tartrate. Adjust pH to 9 with sodium hydroxide solution, filter and wash to obtain levamisole. Adjust the pH to 3-4 with hydrochloric acid, add activated carbon to decolorize, filter, concentrate the filtrate until dry, add acetone to cool to 0℃. Crystallize. Strain and dry to levamisole hydrochloride. In the separation of d-imidazole salt of p-benzoyl tartrate, the mother liquid obtained is the mixed liquid of D-imidazole free base, and racemic tetramidazole is obtained by elimination. Racemidazole can also be resolved using p-toluenesulfonyl glutamic acid or d-camphorsulfonic acid.
| Melting Point | 266-267 °C |
| Specific Rotation | -128 º (c=5, H2O) |
Refractive Index
| -126 ° (C=1, H2O) |
| Flashing Point | 9℃ |
| Solubility | 2-8°C |
| Water Sulobility | Soluble in water, soluble in ethanol (96%), slightly soluble in dichloromethane. |
| Merck | 210 g/L (20 ºC |
| BRN | 14,5459 |
| Sensibility | hygroscopicity |
| LogP | 1.845 (est) |
Our advantages:
1) Timely communication, reply within 12 hours.You can leave any messages on our whatsapp or send email to us.
2)Selecting raw materials strictly,our products are the highest purity.
3)Reasonable and competitive price.
4) Free sample for your evaluation.Customers only need to undertake the shipping fee for delivery the samples to your destionation.
5)OEM/ODM Available.Trial order is available for testing after samples.
6) Packaging can be customized according to each buyers' special request.
We guarantee that your package will pass 100% through the Mexico US, UK, Australia, Netherlands, Canada, France, Germany, Spain, Belgium, Sweden, Poland, Russian, Ukraine, Kazakhstan, Czech Republic, Slovakia, Portugal.
We have freight forwarders in these countries, and our customs clearance company will clear your parcels without any customs issues, sometimes even 1000 kg. Door to door service. Make sure you receive 100% of the goods. Let you have a good experience of our strong freight capacity.
Company Introduction
hebei yanxi chemical co., LTD who registered capital of 10 million yuan, nearly to $2 million, we have a pharmaceutical raw materials factory production of pharmaceutical raw materials, and a reagent r&d center, and we do research and development production of reagent tens of thousands of species. our aim is quality strives for the survival. Seek development by credit reputation. Our products have big price advantage in Europe South America and so on .and Our company also has the advantage of high quality in Africa. in the past two years our products has reached more than 30 countries in the world, Europe. South America. North America, southeast Asia, Africa, etc. We welcome all over the world with the best quality and lowest price friend common cooperation and common development!
After Sales Service
1) Best quality in your requirement
2)Competitive price in china market
3)Mature technical support
4)Professional logistic support
5 )Full experience of large numberscontainers loading in chinese sea port
6 )Fast shipment by reputed shipping line
7) Packing with pallet as buyer's special request
8) Best service after shipment.
9) Cargoes together with container after-sales service available
10) Full experience in export
11)Raw materials from chinese origin
FAQ
What is the way you ship?
Express: FedEx, UPS, EMS, DHL, USPS, TNT, DPD, Aramex etc
Our way of shipping the products is universal and secure.
The company name and other contents related to pharmacy are not written on the package slips.
The way of packing is regularly changed for a secure delivery.
The packages are small in order to avoid unwelcomed questions . If the order is big, then it will be divided into two or more packages
Can the packages be trackable?
YES, we provide tracking number and you can track on internet.
Where do you ship to?
Worldwide.
Do you offer domestic shipping/remail shipping?
Yes we can ship to USA/UK/Canada/Australia/Germany etc warehouse first then to you.
Do you ensure your packing , what about customs, what happens if the package is retained?
We concern a lot about our safety system, we pack the orders as secure as possible. If a package is seized at customs, reships of seized orders will be done provided you have a copy of the letter to show us. If you receive a seizure letter, please contact us immediately with a scanned copy of the seizure letter, and also a new address to have your order reshipped to.
Which payment options are available?
Bitcoin
Western Union
Bank wire
MoneyGram
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