Levamisole name
Chinese name Bao Song Ti
English name levamisole
Chinese alias levamisole | (S) - 6 - phenyl - 2,3,5,6 - four hydrogen - imidazole (2, 1 - B] thiazole | alkali levamisole | sinistral,3,5,6-6 - phenyl - 2-4 hydrogen imidazole and thiazole (2, 1 - B]
More English nicknames
Biological activity of levamisole
Description (S) - (-) -levamisole (Levamisole), an insect repellent with immunomodulatory properties. (S) - (-) -levamisole is a positive allosteric regulator (PAM) of α3β2 (EC50=300μM) and α3β4 (EC50=100μM) isoforms of nAChRs. Oral activity [1][2].
Related category
Research Field > > infection
Signal path > > Transmembrane transport > > Choline receptor
Signal path > > Neural signaling Pathway > > Choline receptor
Research Field > > Inflammation/immunity
In vivo studies (S) - (-) -Levamisole (Levamisole) (50μg/ml and 200μg/ml; p.o.; 30 days) prevented weight gain in mice fed a high-fat diet [2].
Reference literature
[1]. Lewis JA, et al. Levamisole: A Positive Allosteric Modulator for the α3β4 Nicotinic Acetylcholine Receptors Prevents Weight Gain in the CD-1 Mice on a High Fat Diet. Curr Pharm Des. 2017; 23 (12) : 1869-1872.
[2]. Mehta KP, et al. Immunoregulatory treatment for minimal change nephrotic syndrome. Arch Dis Child. 1986; 61 (2) : 153-158.
Physical and chemical properties of levamisole
Density 1.3± 0.1g /cm3
Boiling point 344.4±45.0 °C at 760 mmHg
Melting point 230-233 ºC
Molecular formula C11H12N2S
Molecular weight 204.291
Flash point 162.1±28.7 °C
Accurate mass 204.072113
PSA 40.90000
LogP is 1.85
Appearance properties white to off-white crystalline powder
Vapor pressure 0.0±0.8 mmHg at 25°C
Refractive index 1.713
Storage conditions 0-6°C
China
