| Name | Levodropropizine |
| Description | Levodropropizine ((S)-(-)-Dropropizine) is a histamine receptor inhibitor. It is used as an effective and very well tolerated peripheral antitussive drug. |
| In vitro | Research indicates that Levodropropizine effectively suppresses cough in anesthetized guinea pigs and rabbits. Intravenous administration of Levodropizine in these animals, during mechanically and electrically induced coughs, shows an activity ranging from one-tenth to one-twentieth of codeine, similar to hydroxyzine. Oral Levodropizine treatment for cough induced by irritant aerosols has effects comparable to hydroxyzine and codeine. An intravenous dose of 15 mg/kg Levodropropizine reduces the duration of asphyxiation and the C-fiber response to phenylbiguanide. Additionally, Levodropropizine dose-dependently decreases capsaicin-induced Evans blue dye extravasation in rat airways. |
| In vivo | Levodropropizine exhibits affinity for both H1 histamine and α-adrenergic receptors. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Ethanol : 44 mg/mL (186.2 mM), Sonication is recommended.
H2O : 12 mg/mL (50.78 mM), Sonication is recommended.
DMSO : 55 mg/mL (232.75 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (8.46 mM), Sonication is recommended.
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| Keywords | Levodropropizine | Inhibitor | inhibit | HT | HistamineReceptor | Histamine Receptor | Dropropizine | DF526 | DF 526 | 5HTReceptor | 5HT Receptor |
| Inhibitors Related | Undecane | Alverine citrate | Meclizine dihydrochloride | Dapoxetine hydrochloride | Cefaclor monohydrate | Famotidine | 1,8-Cineole | Sodium butanoate | Alginic acid | Mianserin hydrochloride | Trazodone hydrochloride | Cinchonidine |
| Related Compound Libraries | Bioactive Compound Library | Pain-Related Compound Library | Anti-Neurodegenerative Disease Compound Library | Membrane Protein-targeted Compound Library | EMA Approved Drug Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Anti-Cancer Approved Drug Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | GPCR Compound Library |
United States
