| Name | Levofloxacin hydrate |
| Description | Levofloxacin hydrate (Cravit hydrate) is a broad-spectrum, third-generation fluoroquinolone antibiotic and optically active L-isomer of ofloxacin with antibacterial activity. Levofloxacin diffuses through the bacterial cell wall and acts by inhibiting DNA gyrase (bacterial topoisomerase II), an enzyme required for DNA replication, RNA transcription, and repair of bacterial DNA. Inhibition of DNA gyrase activity leads to blockage of bacterial cell growth. |
| Cell Research | Cell suspension samples (50 mL) (2-5×104 mast cells in each tube for dispersed skin cells or 1 ×105 mast cells in each tube for rat peritoneal cells) in duplicate are equilibrated at 37℃ for 10 min, and then added to polypropylene tubes containing 450 mL test compounds dissolved in Tyrode solution. Histamine release reaction is allowed to proceed for a further 30 min. at the end of which time the reaction is terminated by adding 2 mL ice-cold Tyrode solution and the mixture is centrifuged (450 g for 5 min at 4℃). For determination of total histamine content, mast cells are disrupted in boiling water for 10 min. Histamine concentrations in the resulting supernatant and disrupted cells are determined by the enzyme immunoassay described above. (Only for Reference) |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 50 mg/mL (135 mM), Sonication is recommended.
H2O : 5 mg/mL (13.5 mM), Sonication is recommended.
Ethanol : 10 mg/mL (27 mM), Sonication is recommended.
Methanol : 10 mM, Sonication is recommended.
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| Keywords | Topoisomerase | Topo IV | Topo II | Tavanic Hydrate | Quixin Hydrate | Levofloxacin Hydrate | Levofloxacin | Levaquin Hydrate | Iquix Hydrate | Inhibitor | inhibit | DNAgyrase | DNA/RNA Synthesis | DNA gyrase | Cravit Hydrate | chronic periodontitis | BK Viremia | Bacterial | Antibiotic | airway inflammation |
| Inhibitors Related | Neomycin sulfate | Adipic dihydrazide | Levulinic acid | D(+)-Raffinose pentahydrate | Guanidine hydrochloride | Sulfamethoxazole sodium | Terbinafine hydrochloride | Thymidine | Hyaluronic acid sodium (MW 20 kDa) | Dimethyl sulfoxide | Sodium diacetate | Sodium bicarbonate |
| Related Compound Libraries | Failed Clinical Trials Compound Library | Bioactive Compound Library | EMA Approved Drug Library | Antibiotics Library | Anti-Viral Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Anti-Fibrosis Compound Library | FDA-Approved Drug Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Hematopoietic Toxicity Compound Library |
United States
