| Name | Licochalcone A |
| Description | Licochalcone A is a flavonoid isolated from the famous Chinese medicinal herb Glycyrrhiza uralensis Fisch with obvious anti-cancer effects. |
| Cell Research | The viability of CT-26 mouse colon cancer cells is determined via a MTT assay. In brief, colon cancer cells are seeded onto each well of a 96-well plate with DMEM containing 10% FBS and cultured to adhere overnight. The cells are then treated with various concentrations of LCA in serum-free medium for 24 and 72 hr, respectively. Twenty microlitres of a MTT solution (5 mg/ml) is added to each well, and the cells are incubated for 4 hr at 37°. The medium is then removed, and 200 μL of dimethyl sulfoxide is added to each well. The absorbance is determined at 570 nm using a microplate reader.(Only for Reference) |
| In vitro | Licochalcone A markedly inhibits the in vitro growth of L. major amastigotes in human MDMs and U937 cells. [1] Licochalcone A shows antibacterial effects against all gram-positive bacteria tested and especially against all Bacillus spp. Tested with MICs of 2 to 3 micrograms/mL. [3] In CT-26 colon cancer cells, Licochalcone A reduces the cell viability and DNA synthesis. [4] Licochalcone A also interferes with MAPK signaling cascades, initiates ROS generation, induces oxidative stress and consequently causes BGC cell apoptosis. [5] |
| In vivo | In mice infected with L. major, licochalcone A (5 mg/kg, i.p.) completely prevents lesion development. In mice infected with L. donovani, licochalcone A (150 mg/kg, p.o.) results in > 65 and 85% reductions of parasite loads in the liver and the spleen, respectively. [2] In CT-26 cell-inoculated Balb/c mice, licochalcone A (1 mg/kg, p.o.) inhibits the tumor growth, and alleviates cisplatin-induced nephrotoxicity and hepatotoxicity. [4] |
| Storage | Store at low temperature | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | Chloroform : Soluble
H2O : < 1 mg/mL (insoluble or slightly soluble)
15% Cremophor EL : 5.00 mg/mL (14.78 mM), Solution.
DMSO : 250.00 mg/mL (738.77 mM), Sonication is recommended.
Ethanol : 67.00 mg/mL (197.99 mM), Sonication is recommended.
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| Keywords | UGT1A1 | Licochalcone-A | Licochalcone A | Inhibitor | inhibit | Caspase-3 | Autophagy |
| Inhibitors Related | Stavudine | Aceglutamide | Hemin | Tamoxifen | Cysteamine hydrochloride | Guanidine hydrochloride | Hydroxychloroquine | Cremophor EL | Paeonol | Naringin | Alginic acid | Sildenafil citrate |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Flavonoid Natural Product Library | Traditional Chinese Medicine Monomer Library | Anti-Neurodegenerative Disease Compound Library | Membrane Protein-targeted Compound Library | Selected Plant-Sourced Compound Library | Drug Repurposing Compound Library | Miao medicine Compound Library | Natural Product Library for HTS | Anti-Aging Compound Library | Ancient Chinese Classical Formulas Compound Library | Anti-Cancer Drug Library |
United States
