| Name | Linsidomine hydrochloride |
| Description | Linsidomine hydrochloride (SIN-1 chloride) is considered as a metabolite of moxidomine, with vasodilation, inhibition of platelet aggregation, and antiangina activity. In myocardial ischemia-reperfusion models, Linsidomine hydrochloride to reduce myocardial necrosis and reperfusion induced endothelial dysfunction is associated with the cavernosal mechanism of action involved in nitric oxide release. |
| In vitro | SIN-1 decreases myocardial necrosis and reperfusion-induced endothelial dysfunction in models of myocardial ischemia-reperfusion [1][2]. |
| In vivo | SIN-1 (chloride) is the active metabolite of molsidomine. SIN-1 (chloride) exhibits a potent vasorelaxant effect and inhibition of platelet aggregation.[1]
SIN-1 (chloride) decreases myocardial necrosis and reperfusion-induced endothelial dysfunction in models of myocardial ischemia-reperfusion.[2] |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 22.5 mg/mL (108.89 mM), Sonication and heating to 60℃ are recommended.
10% DMSO+40% PEG300+5% Tween-80+45% Saline : 2 mg/mL (9.68 mM), Sonication is recommended.
H2O : 45 mg/mL (217.78 mM), Sonication is recommended.
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| Keywords | SIN-1 Chloride | SIN1 Chloride | SIN 1 Chloride | Linsidomine Hydrochloride | DrugMetabolite | Drug Metabolite |
| Inhibitors Related | Ethoxyquin | Kaolin | Stavudine | Aceglutamide | Allopurinol | Hemin | Guanidine hydrochloride | Hydroxychloroquine | Ethyl linoleate | Formamide | Paeonol | Alginic acid |
| Related Compound Libraries | NF-κB Signaling Compound Library | Bioactive Compound Library | Anti-Cardiovascular Disease Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Compound Library | Transcription Factor-Targeted Compound Library |
United States
