| Name | LMPTP INHIBITOR 1 dihydrochloride |
| Description | LMPTP Inhibitor 1 Dihydrochloride is a compound selectively targeting low molecular weight protein tyrosine phosphatase (LMPTP), exhibiting potent inhibitory activity with an IC50 value of 0.8 μM for LMPTP-A. |
| In vitro | LMPTP INHIBITOR 1 dihydrochloride is a selective inhibitor of low molecular weight protein tyrosine phosphatase, with an IC50?of 0.8 μM LMPTP-A and shows more potent effect on LMPTP-A versus LMPTP-B. LMPTP inhibitor 1 dihydrochloride (10 μM) also enhances HepG2 IR phosphorylation after insulin stimulation in human HepG2 hepatocytes[1]. |
| In vivo | LMPTP inhibitor 1 dihydrochloride, an orally bioavailable compound, achieves an approximate mean serum concentration of 680 nM following 0.03% w/w administration and exceeds 3 μM with 0.05% w/w dosage. Notably, it reverses diabetes in obese mice. At a concentration of 0.05% w/w, it effectively inhibits LMPTP activity, leading to a significant enhancement in glucose tolerance and a reduction in fasting insulin levels in diabetic DIO mice, with no impact on body weight[1]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | H2O : 50 mg/mL (96.61 mM), Sonication is recommended.
DMSO : 64 mg/mL (123.66 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (3.86 mM), Sonication is recommended.
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| Keywords | protein tyrosine phosphatase(PTP) | Phosphatase | LMPTP inhibitor-1 | LMPTP inhibitor1 | LMPTP INHIBITOR 1 dihydrochloride | LMPTP inhibitor 1 | Inhibitor | inhibit |
| Inhibitors Related | β-Glycerophosphate disodium salt pentahydrate | Hexane-1,6-diol | 2-[dodecyl(2-hydroxyethyl)amino]ethanol | Idoxuridine | Cyclosporine | Tartaric acid disodium dihydrate | Stearic acid | CaMKP Inhibitor | L-Ascorbic acid 2-phosphate magnesium | Cyclosporin A | L-Ascorbic acid 2-phosphate | β-Glycerophosphate disodium salt hydrate |
| Related Compound Libraries | Glycometabolism Compound Library | Bioactive Compound Library | Inhibitor Library | Metabolism Compound Library | Bioactive Compounds Library Max | Phosphatase Inhibitor Library |
United States
