| Name | Lomerizine dihydrochloride |
| Description | Lomerizine dihydrochloride (KB-2796) is an antagonist of L- and T-type voltage-gated calcium channels used to treat migraine. |
| In vitro | Treatment of rat retinal neurons cultured in vitro with 0.1 μM and 1 μM Lomerizine significantly reduced glutamate-induced neurotoxicity.1 μM Lomerizine showed a protective effect against N-methyl-D-aspartic acid- and haemonucleic acid-induced types of neurotoxicity in cultured rat retinal neurons. |
| In vivo | Treatment of rat retinal neurons cultured in vitro with 0.1 μM and 1 μM Lomerizine significantly reduced glutamate-induced neurotoxicity.1 μM Lomerizine showed a protective effect against N-methyl-D-aspartic acid- and haemonucleic acid-induced types of neurotoxicity in cultured rat retinal neurons. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 15 mg/mL (27.7 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (3.69 mM), Sonication is recommended. H2O : < 1 mg/mL (insoluble or slightly soluble) Ethanol : 49 mg/mL (90.5 mM), Sonication is recommended.
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| Keywords | T-type calcium channel | L-type calcium channel | Lomerizine Hydrochloride | Lomerizine dihydrochloride | Lomerizine | KB2796 | KB 2796 | Inhibitor | inhibit | CalciumChannel | Calcium Channel | Ca2+ channels | Ca channels |
| Inhibitors Related | Quadrol | Tricaine methanesulfonate | Nisoldipine | 2,4,6-Tri-tert-butylphenol | Chlorocresol | L-Ascorbic acid | L-Phenylalanine | L-Ascorbic acid sodium salt | 1-Octanol | 2-Nitrobenzoic acid | Magnesium Chloride Hexahydrate | Magnesium sulfate |
| Related Compound Libraries | Pain-Related Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Neuroprotective Compound Library | NO PAINS Compound Library | Anti-Cancer Approved Drug Library | Bioactive Compounds Library Max | Ion Channel Targeted Library | Anti-Cancer Drug Library |