Lomustine NEW

Manufacturer Provide Pharmaceutical Intermediates Lomustine CAS 13010-47-4 API Anti-Cancer Lomustine Powder

Introduction

Product Name: Lomustine

Other Name :(chloro-2-ethyl)-1-cyclohexyl-3-nitrosourea;(cloro-2-etil)-1-cicloesil-3-nitrosourea;1-(2-chloroethyl)-3-cyclohexyl-1-nitrosoure;1-(2-chloroethyl)-3-cyclohexyl-1-nitroso-ure;belustine

CAS NO: 13010-47-4

Purity: 99%min
Appearance:Yellow Powder

Molecular formula: C9H16ClN3O2

Molecular weight :233.7

Melting Point :88-90°C

Boiling Point :63.6°C (rough estimate)

Density :1.3840 (rough estimate)

Storage:Sealed in dry,Room Temperature

Lomustine (CCNU), chemically known as 1-(2-chloroethyl) -3-cyclohexyl-1-nitrosourea, is an organic compound with the chemical formula C9H16ClN3O2. It is an alkylating agent and a cell cycle non-specific product. It is most sensitive to cells at the G1-S boundary or early S stage, and also has an inhibitory effect on G2 stage.

Application 

1, strong fat solubility, can enter the cerebrospinal fluid, often used for primary brain tumors (such as glioblastoma) and secondary tumors;
2, the treatment of solid tumors, such as combined with fluorouracil for gastric and rectal cancer, combined with methotrexate, cyclophosphamide for bronchial lung cancer;
3. Treatment of Hodgkin's disease.