| Name | Loxoribine |
| Description | Loxoribine (RWJ 21757) is a guanosine analog. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist. It has anti-viral and anti-tumor activities.Loxoribine is a potent new immunostimulant with a relatively broad spectrum of immunobiological activities. |
| In vitro | Loxoribine selectively activates innate immune system cells through the Toll-like receptor (TLR) 7/MyD88-dependent signaling pathway[1], leading to the maturation of human monocyte-derived dendritic cells (DCs) and enhancing their Th-1- and Th-17-polarizing capability[2]. Additionally, loxoribine (250 μM; 48 hours) promotes MoDCs maturation, evident from the increased expression of CD80, CD83, CD40, CD54, and CCR7[2]. |
| In vivo | In vivo, Loxoribine (2 mg; s.c.or i.v.) activates murine natural killer (NK) cells[3]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (5.89 mM), Sonication is recommended. DMSO : 27.5 mg/mL (81.05 mM), Sonication is recommended.
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| Keywords | Toll-like Receptor (TLR) | TLR-7 | TLR7 | TLR | RWJ-21757 | RWJ21757 | natural | MoDCs | Loxoribine | killer,cells | Inhibitor | inhibit | InfluenzaVirus | Influenza Virus | cells |
| Inhibitors Related | Rifampicin | Acetylcysteine | Hydroxychloroquine | Benzyl alcohol | Nitazoxanide | Chloroquine phosphate | Curcumin | Baicalein | Thiamine hydrochloride | Salcomine | Benzimidazole | β-Cyclodextrin |
| Related Compound Libraries | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Pyroptosis Compound Library | Drug Repurposing Compound Library | Anti-Viral Compound Library | Orally Active Compound Library | Immuno-Oncology Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Infection Compound Library | Anti-Cancer Active Compound Library | Anti-Cancer Drug Library |