| Name | LP-922056 |
| Description | LP-922056 is an inhibitor of Notum Pectinacetylesterase with EC50 values of 21 nM, 55 nM for human and mouse, respectively. |
| In vitro | LP-922056 can be used as a complementary chemical tool for exploring the role of Notum in Wnt signaling[2]. |
| In vivo | In mice, LP-922056 (3, 10, 30 mg/kg; gavage) significantly increases midshaft femur cortical bone thickness. LP-922056 (10 mg/kg) achieved high Cmax of 129 μM and AUC of 1533 μM•h while volume of distribution is 0.13 L/kg and low clearance is 0.49 mL/min•kg[1]. LP-922056 (10 mg/kg; oral) increases cortical bone thickness and strength in the midshaft femur, bone mass in the femoral neck, and vertebral body cortical shell[2]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 4 mg/mL (13.3 mM), Sonication is recommended. DMSO : 120 mg/mL (398.96 mM), Sonication is recommended.
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| Keywords | βcatenin | Wnt/β-catenin | Wnt/betacatenin | Wnt/b-catenin | Wnt | thickness | Pectinacetylesterase | orally | Notum | midshaft | LP-922056 | LP922056 | LP 922056 | lipase | Inhibitor | inhibit | femur | cortical | bone | beta-catenin | betacatenin | bcatenin |
| Inhibitors Related | Chlorquinaldol | Urea | Wnt pathway activator 1 | Neohesperidin | XAV-939 | Ethyl linoleate | Monensin sodium salt | Nimbolide | Isoquercetin | (±)-Nornicotine | Methyl Vanillate | Bisdemethoxycurcumin |
| Related Compound Libraries | Reprogramming Compound Library | Anti-Pancreatic Cancer Compound Library | Bioactive Compound Library | Anti-Alzheimer's Disease Compound Library | Hematonosis Compound Library | Neuroprotective Compound Library | Inhibitor Library | Anti-Fibrosis Compound Library | Bioactive Compounds Library Max | Cytoskeletal Signaling Pathway Compound Library | Wnt/Hedgehog/Notch Compound Library | Anti-Liver Cancer Compound Library |