| Name | LY310762 |
| Description | LY310762 is a 5-HT1D receptor antagonist with Ki of 249 nM. |
| In vitro | Following treatment with LY310762, the levels of 5-HT in animals treated with fluoxetine increased from 312±43% to a peak of 683%. In the control group, the 5-HT levels remained constant at 250%. Compared to animals that received a control vehicle injection, systemic administration of 10 mg/kg i.p. LY310762 significantly enhanced the response of 5-HT to 20 mg/kg i.p. fluoxetine. When administered alone, LY310762 notably raised the baseline levels of 5-HT above the vehicle control, achieving a maximum value of 258% compared to the pre-injection control group. |
| In vivo | LY310762 enhances potassium-induced [3H] 5-HT efflux from guinea pig cortical slices, with an EC50 of 30 nM. The maximal enhancement of potassium-induced [3H]5-HT efflux by LY310762 is approximately 40%. LY310762 exhibits a higher affinity for the guinea pig 5-HT1D receptor than for the 5-HT1B receptor. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 1 mg/mL (2.32 mM), Sonication is recommended.
DMSO : 43.1 mg/mL (100.01 mM), Sonication is recommended.
H2O : 4.31 mg/mL (10 mM), Sonication is recommended.
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| Keywords | LY-310762 | LY310762 | LY 310762 | 5HTReceptor | 5-HT1D | 5-HT Receptor | 5HT Receptor |
| Inhibitors Related | Alverine citrate | Sevoflurane | Dapoxetine hydrochloride | Cefaclor monohydrate | Clozapine N-Oxide | 1,8-Cineole | Dopamine hydrochloride | Cloperastine hydrochloride | Mianserin hydrochloride | Trazodone hydrochloride | Cinchonidine | Doxepin hydrochloride |
| Related Compound Libraries | Target-Focused Phenotypic Screening Library | Anti-Neurodegenerative Disease Compound Library | Pain-Related Compound Library | Bioactive Compound Library | Neuronal Signaling Compound Library | Anti-Alzheimer's Disease Compound Library | Membrane Protein-targeted Compound Library | Inhibitor Library | Bioactive Compounds Library Max | Fluorochemical Library | GPCR Compound Library | Anti-Cancer Compound Library |
United States
