Property Description
Chemical Name：Lypressin Acetate
CAS:50-57-7
Synonyms：8-Lysine-vasopressin acetate, Lysine vasopressin acetate, LVP
Molecular Formula：C₄₆H₆₅N₁₃O₁₂S₂
Molecular Weight：Approximately 1056.23 g/mol
Structure ：Synthetic vasopressin analogue with lysine replacing arginine at position 8.
Appearance：White to off-white powder
Solubility：Soluble in water, slightly soluble in ethanol
Stability：Stable when stored in a cool, dry place, protected from light and moisture
Biological Activity：Acts on V1 and V2 receptors; antidiuretic and vasoconstrictive effects
Pharmacological Use：
- Treatment of diabetes insipidus (reduces urine output)
- Vasoconstrictor (increases blood pressure in certain conditions)
Storage：Store at 2-8°C (36-46°F) in a tightly sealed container
Safety：- Handle with care, avoid inhalation or direct contact with skin/eyes
- Toxicity data limited; use under medical supervision
Regulatory Status:Approved for medical use in some countries; availability may vary
Lypressin acetate is a synthetic peptide analogue of vasopressin, primarily used for its antidiuretic effects in treating diabetes insipidus. It is a stable, water-soluble compound with vasoconstrictive properties. Proper storage and handling are essential for maintaining its efficacy and safety.
Test Parameters and Results
| Parameter | Specification | Result | Test Method |
|---|
| Appearance | White to off-white powder | Complies | Visual Inspection |
| Purity (HPLC) | ≥ 98.0% | 99.2% | HPLC |
| Water Content | ≤ 5.0% | 3.8% | Karl Fischer Titration |
| Heavy Metals | ≤ 10 ppm | < 5 ppm | ICP-MS |
| Residual Solvents | Complies with ICH Q3C | Complies | GC |
| Biological Activity | ≥ 95% of labeled potency | 98.5% | In vitro assay |
| Microbial Limits | Complies with USP <61> | Complies | Microbial Testing |
Additional Information
Storage Conditions: Store at 2-8°C, protected from light and moisture.
Shelf Life: 24 months from the date of manufacture when stored properly.
China
