| Name | M8-B Hydrochloride |
| Description | M8-B Hydrochloride is a selective transient receptor potential melastatin-8 (TRPM8) channel antagonist. |
| Animal Research | Eight day old male Wistar rat pups were used for induction of febrile seizure.?M8 B and diazepam were injected intraperitoneally.?The rat pups were then transferred to a heated plexiglas chamber and the latency to the first febrile seizure was measured.?In addition, different groups of mice were pretreated with M8 B and received a convulsant dose of pentylenetetrazol (PTZ).?Latencies to stages 2 and 4 and duration of stage 5 seizure episodes were measured.The effect of M8 B on electroshock induced seizures was also investigated and hindlimb extension time was measured[1]. |
| In vivo | M8 B, a TRPM8 antagonist, can reduce body temperature.M8 B decreased the body temperature of rat pups and increased the latency to the first febrile seizure, implying a significant protective effect.?It also induced a significant anticonvulsant effect in PTZ but not electroshock induced convulsions.?M8 B showed anticonvulsant effects in both febrile and PTZ induced seizures.?M8 B had a hypothermic effect with significant protective effects on febrile and PTZ induced seizures. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (4.62 mM), Sonication is recommended.
DMSO : 27.5 mg/mL (63.52 mM), Sonication is recommended.
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| Keywords | TRPVChannel | TRPV Channel | TRPM8 | TRPChannel | TRP Channel | M8-B Hydrochloride | M-8-B Hydrochloride | M8B Hydrochloride | M8 B Hydrochloride |
| Inhibitors Related | (+)-Camphor | Rosiglitazone | Caffeic Acid | Oleoyl Serotonin | (-)-Menthol | Camphor | Probenecid | Pregnenolone | Nonivamide | 1,4-Cineole | trans-Cinnamaldehyde | Methyl salicylate |
| Related Compound Libraries | Pain-Related Compound Library | Bioactive Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Anti-Parkinson's Disease Compound Library | Inhibitor Library | NO PAINS Compound Library | Bioactive Compounds Library Max | Ion Channel Targeted Library | Anti-Cancer Compound Library |
United States
