| Name | MAO-IN-M30 dihydrochloride |
| Description | MAO-IN-M30 dihydrochloride is a highly potent non-selective inhibitor of MAO-A and MAO-B (IC50 < 0.1 μM). MAO-IN-M30 dihydrochloride is orally active and can cross the blood-brain barrier. It is an effective iron chelator and free radical scavenger. MAO-IN-M30 dihydrochloride has neuroprotective activity in in vitro and in vivo models of Parkinson's disease (PD). It increases brain dopamine, serotonin and norepinephrine and can serve as a lead drug for the development of multifunctional drugs to treat various neurodegenerative diseases. |
| In vitro | MAO-IN-M30 (0.25 nM; 72 hours) significantly increased cell viability to ~90% after exposure to Dexamethasone and reduced the occurrence of fragmented DNA compared to the dexamethasone-treated group in SH-SY5Y cells[3]. Additionally, MAO-IN-M30 (0-10 μM; 24 hours) enhances PC12 cell survival[4]. |
| In vivo | MAO-IN-M30 (0.5-2.5 mg/kg; p.o.; once daily for 14 consecutive days) exhibits neuroprotective activities [6]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 1.8 mg/mL (6.02 mM), Sonication and heating to 60℃ are recommended.
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| Keywords | MonoamineOxidase | Monoamine Oxidase | MAO-IN-M30 Dihydrochloride | MAO-IN-M30 | M-30 Dihydrochloride | M30 Dihydrochloride | M-30 | M30 | M 30 Dihydrochloride | M 30 |
| Inhibitors Related | Safinamide | Indazole | 1,4-Naphthoquinone | Paeonol | Hydroxylamine hydrochloride | Isatin | Methylene Blue | Methylene Blue trihydrate | β-Aminopropionitrile | Aminoacetone hydrochloride | D-(-)-Quinic acid | Amitraz |
| Related Compound Libraries | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Antidepressant Compound Library | Antioxidant Compound Library | CNS-Penetrant Compound Library | Neuroprotective Compound Library | Inhibitor Library | Mitochondria-Targeted Compound Library | Orally Active Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Covalent Inhibitor Library |
United States
