| Name | Matrine |
| Description | Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist. |
| In vitro | In human non-small cell lung cancer A549 and hepatocellular carcinoma SMMC-7721 cells, Matrine inhibits cell growth. Particularly, in A549 cells, Matrine induces apoptosis by reducing the Bcl-2 / Bax protein ratio. |
| In vivo | In mice, the median lethal dose (LD50) of Matrine administered via intraperitoneal injection is 157 mg/kg. |
| Storage | 02 | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (8.05 mM), Sonication is recommended. Ethanol : 49 mg/mL (197.29 mM), Sonication is recommended. H2O : 20 mg/mL (80.53 mM), Sonication is recommended. DMSO : 45 mg/mL (181.19 mM), Sonication is recommended.
|
| Keywords | κ-opioid receptor | OpioidReceptor | Opioid Receptor | Non-small cell lung cancer | Mitophagy | Matrine | hepatoma | Ferroptosis | Autophagy | anti-oxidative stress | a-Matrine | alpha-Matrine | acute kidney injury (AKI) model | A549 cells |
| Inhibitors Related | Stavudine | Aceglutamide | Hemin | Urea | Tamoxifen | Guanidine hydrochloride | Hydroxychloroquine | Metronidazole | Formamide | Paeonol | Naringin | Alginic acid |
| Related Compound Libraries | Pesticide Compound Library | Traditional Chinese Medicine Monomer Library | Anti-Neurodegenerative Disease Compound Library | Pain-Related Compound Library | Membrane Protein-targeted Compound Library | Drug Repurposing Compound Library | Natural Product Library for HTS | Bioactive Compounds Library Max | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library | GPCR Compound Library | Ancient Chinese Classical Formulas Compound Library | Anti-Cancer Drug Library |