| Name | Medetomidine |
| Description | Medetomidine (MPV785 free base) is a selective and orally available α2-adrenoceptor agonist, Ki=1.08 nM, with sedative and analgesic effects and vasoconstrictive hypoxic side effects, and is commonly used in small animal anesthesia. |
| In vitro | Both enantiomers of Medetomidine (dex- and levoMedetomidine) inhibit cytochrome P450-dependent drug-metabolizing activity in rat and human liver microsomes(100 μg/kg ;from 17 to 23 min.; both enantiomers)[1]. In Rainbow trout(i.p. injection;<5 μmol/kg) or water exposure (<50 nM) caused a 2–7 fold increase in hepatic EROD activity[2]. |
| In vivo | In rat models, Medetomidine exhibits dose-dependent sedative and analgesic effects. High doses (>100 μg/kg) can result in loss of righting reflex and hypothermia[3]. In anesthetized rats, Medetomidine induces transient hypotension and bradycardia. In denervated rats, it shows potent vasopressor activity (PD₅₀ = 1.7 μg/kg) and suppresses sympathetic nerve activity (ID₅₀ = 1.6 μg/kg)[3]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 200 mg/mL (998.6 mM), Sonication is recommended.
H2O : < 1 mg/mL (insoluble), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 5 mg/mL (24.97 mM), Sonication is recommended.
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| Keywords | Medetomidine |
| Inhibitors Related | Trifluoperazine dihydrochloride | Mirtazapine | Octopamine hydrochloride | Gemfibrozil | Buflomedil hydrochloride | Dexmedetomidine hydrochloride | Isoprenaline hydrochloride | D-Mannitol | Mianserin hydrochloride | Trazodone hydrochloride | Atenolol | Doxepin hydrochloride |
| Related Compound Libraries | Bioactive Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Neurotransmitter Receptor Compound Library | Animal Drug Library | Bioactive Compounds Library Max | GPCR Compound Library |
United States
