| Name | Menthone |
| Description | Menthone has anti-inflammary activity,, it can suppress the lipopolysaccharide (LPS)-induced proinflammatory cytokines, interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha),as well as nuclear factor kappaB (NF-kB). |
| Animal Research | Adult male albino Wistar rats with average weight of 250±10 gr, were divided into six groups (n=18/each), as: ACV (15 mg/kg/day), ACV+Vit C (20 mg/kg/day), ACV+ menthone (100 μl/d), ACV+ menthone (250 μl/d), ACV+ menthone (400 μl/day) and control group without any treatment. At the end of experiment, the animals were sacrificed and sperm samples were collected and isolated in phosphate-buffered saline and examined by TUNEL staining process. The percentage of TUNEL positive spermatozoa was evaluated by fluorescence microscopy. Each experiment was performed in three repeats |
| In vivo | Menthone and Vit C at higher dose have a good compensatory effect with significant reduction in DNA damages in sperm cells by reversing the adverse effect of ACV on the reproductive system in male rat. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2 mg/mL (12.97 mM), Sonication is recommended.
DMSO : 250 mg/mL (1620.75 mM), Sonication is recommended.
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| Keywords | volatile | TNF-α | Parasite | NF-κB | NFκB | NF-kB | NFkB | Menthone | Inhibitor | inhibit | ILReceptor | IL Receptor | antioxidant | anti-Inflammatory |
| Inhibitors Related | Kaolin | Gum arabic | Kojic acid | Hydroxychloroquine | Metronidazole | Avermectin B1a | 2-Amino-2-methyl-1-propanol | Doxycycline | 1,8-Cineole | Ethyl linoleate | Fenpyroximate | Methylene Blue trihydrate |
| Related Compound Libraries | Terpene Natural Product Library | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Natural Product Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Tobacco Monomer Library | Natural Product Library for HTS | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Anti-infective Natural Product Library | Bioactive Compounds Library Max | Ancient Chinese Classical Formulas Compound Library |
United States
