Mexidole

Ethylmethylhydroxypyridine Succinate (Mexidol® API)
Dual-Action Neuroprotective Agent & Antioxidant

Key Specifications:

• CAS: 127464-43-1

• Formula: C₁₀H₁₇NO₄·C₄H₆O₄

• Purity: ≥99.7% (HPLC)

• Appearance: White crystalline powder

• Solubility: 50 mg/mL in saline

Mechanistic Advantages:
✓ Scavenges hydroxyl/peroxyl radicals
✓ Stabilizes neuronal cell membranes
✓ Enhances cerebral blood flow
✓ Low CYP450 interaction risk

Clinical Applications:
• Ischemic stroke recovery
• Anxiety disorder management
• Alcohol withdrawal therapy
• Traumatic brain injury rehabilitation

Manufacturing Compliance:

• WHO-GMP certified synthesis

• ICH Q3D elemental impurities compliant

• USDMF II/1831 active

Packaging:
1kg/5kg nitrogen-sealed vials
25kg controlled atmosphere drums

Stability: 36 months at 15-25°C (desiccated)

Competitive Differentiation:

1. Dual MOA (Antioxidant + Membrane Stabilizer)

2. Superior BBB penetration vs. edaravone

3. Pre-filled syringe compatible formulation

4. Complete preclinical/clinical dossier available