| Name | Mitochonic acid 5 |
| Description | Mitochonic acid 5 (MA-5) is a derivative of the plant hormone indole-3-acetic acid. Mitochonic acid 5 binds mitochondria and ameliorates renal tubular and cardiac myocyte damage.It has been shown to improve survival of fibroblasts from patients with mitochondrial diseases. |
| Cell Research | TNFα was used to induce inflammatory injury in mouse microglial BV-2 cells with and without prior MA-5 treatment. Cellular apoptosis was assessed using the MTT and TUNEL assays. Mitochondrial functions were evaluated via mitochondrial membrane potential JC-1 staining, ROS flow cytometry analysis, mPTP opening assessment, and immunofluorescence of cyt-c. Mitophagy was examined using western blots and immunofluorescence. The pathways analysis was carried out using western blots and immunofluorescence with a pathway blocker[1]. |
| In vitro | Treatment with MA-5 reduced mitochondrial apoptosis via upregulation of mitophagy.?Increased mitophagy degraded damaged mitochondria, disrupting mitochondrial apoptosis, neutralizing ROS overproduction, and improving cellular energy production.?We also identified that MA-5 regulated mitophagy via Bnip3 through the MAPK-ERK-Yap signaling pathway.?Inhibiting this signaling pathway or knocking down Bnip3 expression prevented MA-5 from having beneficial effects on mitochondrial homeostasis and increased microglial apoptosis[1]. |
| Storage | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 34.29 mg/mL (104.13 mM), Sonication is recommended.
10% DMSO+40% PEG300+5% Tween 80+45% Saline : 3.3 mg/mL (10.02 mM), Sonication is recommended.
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| Keywords | Mitochonic acid-5 | Mitochonic acid5 | Mitochonic acid 5 | MitochondrialMetabolism | Mitochondrial Metabolism | MA5 | MA 5 | Inhibitor | inhibit |
| Inhibitors Related | Ciprofloxacin hydrochloride monohydrate | Phenoxyethanol | 1-Hexanol | Imeglimin hydrochloride | Rotenone | Ciprofloxacin monohydrochloride | (-)-Epigallocatechin Gallate | Phosphocreatine disodium | Sodium Molybdate | 4-Pentenoic acid | 4'-Hydroxychalcone | L-Histidine |
| Related Compound Libraries | Glycometabolism Compound Library | Bioactive Compound Library | Natural Product Library | Stem Cell Differentiation Compound Library | NO PAINS Compound Library | Mitochondria-Targeted Compound Library | Natural Product Library for HTS | Lipid Metabolism Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Fluorochemical Library | Anti-Metabolism Disease Compound Library |
United States
